Chemistry, Ames Laboratory
Journal or Book Title
ACS Symposium Series
A bicatalytic system was prepared by the immobilization of alcohol oxidase enzyme and an alkylamine organocatalyst in distinct locations of mesoporous nanoparticles. The resulting nanocomposites were able to perform a sequence of oxidation and aldol coupling reactions, which transformed short chain alcohols into longer chain molecules. The process takes place at low temperatures, but requires additional enzyme (catalase) to prevent inactivation of the catalyst. This qualitative study introduces a model of a hybrid multicomponent nanomaterial that resembles the behavior of multienzymatic systems within confined spaces.
American Chemical Society
Kandel, Kapil; Althaus, Stacey Marie; Pruski, Marek; and Slowing, Igor I., "Supported Hybrid Enzyme-Organocatalysts for Upgrading the Carbon Content of Alcohols" (2013). Ames Laboratory Publications. 311.