Toll-Like Receptor Signaling in Bovine Macrophages Increases 1,25-Dihydroxyvitamin D3 Production

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R2276.pdf (39.45 KB)
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2008-01-01
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Nelson, Corwin
Beitz, Donald
Reinhardt, Tim
Lippolis, John
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Abstract

Recognition of pathogen associated molecular patterns by Toll-like receptors (TLR) increases 1α-hydroxylase expression in bovine macrophages. This results in increased conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1,25- dihydroxyvitamin D3 (1,25(OH)2D3) in bovine macrophages. Production of 1,25(OH)2D3 in bovine macrophages indicates that 1,25(OH)2D3 may be involved in modulating the bovine immune response.
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https://doi.org/10.31274/ans_air-180814-482
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https://dr.lib.iastate.edu/handle/20.500.12876/8473
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Agriculture
Animal Sciences
Beef Science
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ASL R2276
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Tue Jan 01 00:00:00 UTC 2008
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