Direct genomic breeding values (DGV) based on actual or imputed GeneSeek Genomic Profiler HD (GGPHD) genotypes were obtained for birth, weaning and yearling weights using Bayesian regression on about 20,000 US Simmental pure- or cross-bred beef cattle. Accuracies of DGV were quantified using 4-fold cross validation. Accuracies expressed as genetic correlations between DGV and trait ranged from 0.61 to 0.65, and the regressions of phenotype on DGV ranged from 0.61 to 0.66. These results indicate good predictive ability of genomic prediction with GGPHD chips but DGV need to be adjusted for bias.