Veterinarians have a tremendous responsibility— and opportunity— to help their clients prepare for a potential foot and mouth disease (FMD) outbreak. While eradication of FMD, should it occur in the U.S., is the ultimate goal, the old approach to FMD response— massive depopulation— is no longer workable except in a small outbreak. The size, structure, efficiency and extensive movement in cattle production will likely require alternative response options to manage disease spread, such as vaccination and allowing animals to recover.