Summary and Implications
The tumorigenesis caused by avian leukosis virus (ALV) occurs through a complex regulatory architecture. , We applied a novel methodology to jointly analyze four different types of datasets: mRNA expression, the associated regulatory factors of miRNA and lncRNA, and ALV gene expression. The pathway analysis shows that combined analysis produced more informative results than single data-type analyses, and the co-expression network analysis found key elements involved in the host-pathogen interaction. The integration of multiple data sources yielded deeper insights into the pathogenesis of the virus and the host immune response.
Iowa State University
Lan, Xi; Hsieh, John C.F.; Liu, Haibo; Lamont, Susan J.; and Zhu, Qing
"Integration of Host and Virus Gene Expression for Chickens Response to Avian Leukosis Virus Challenge,"
Animal Industry Report:
AS 664, ASL R3255.
Available at: https://lib.dr.iastate.edu/ans_air/vol664/iss1/53