Document Type

Article

Publication Version

Published Version

Publication Date

6-2015

Journal or Book Title

Journal of Veterinary Pharmacology and Therapeutics

Volume

38

Issue

3

First Page

209

Last Page

312

DOI

10.1111/jvp.12170

Abstract

The purpose of this study was to compare the pharmacokinetics of meloxicam in mature swine after intravenous (IV) and oral (PO) administration. Six mature sows (mean bodyweight ± standard deviation = 217.3± 65.68 kg) were administered an IV or PO dose of meloxicam at a target dose of 0.5 mg/kg in a cross-over design. Plasma samples collected up to 48 hours post-administration were analyzed by high pressure liquid chromatography and mass spectrometry (HPLC-MS) followed by non-compartmental pharmacokinetic analysis. Mean peak plasma concentration (CMAX) after PO administration was 1070 ng/ml (645-1749 ng/ml). TMAX was recorded at 2.40 hour (0.50-12.00 hours) after PO administration. Half-life (T ½ λz) for IV and PO administration was 6.15 hours (4.39-7.79 hours) and 6.83 hours (5.18-9.63 hours) respectively. The bioavailability (F) for PO administration was 87% (39-351%). The results of the present study suggest that meloxicam is well absorbed after oral administration.

Comments

This is a manuscript of an article from Journal of Veterinary Pharmacology and Therapeutics 38 (2015): 265, doi:10.11 11/jvp.12170. Posted with permission.

Copyright Owner

Pairis-Garcia, M.D., et al.

Language

en

File Format

application/pdf

Published Version

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