Authors

Martien A. M. Groenen, Wageningen University
Alan Archibald, University of Edinburgh
Hirohide Uenishi, National Institute of Agrobiological Science, Japan
Christopher K. Tuggle, Iowa State UniversityFollow
Yasuhiro Takeuchi, University College London
Max F. Rothschild, Iowa State UniversityFollow
Claire Rogel-Gaillard, Institut National de la Recherche Agronomique
Chankyu Park, Konkuk University
Denis Milan, Institut National de la Recherche Agronomique
Hendrik-Jan Megens, Wageningen University
Shengting Li, Beijing Institute of Genomics of Chinese Academy of Sciences
Denis M. Larkin, Aberystwyth University
Heebal Kim, Seoul National University
Laurent A. F. Frantz, Wageningen University
Mario Caccamo, Genome Analysis Centre, Norwich, UK
Hyeonju Ahn, Seoul National University
Bronwen L. Aken, Wellcome Trust Sanger Institute, UK
Anna Anselmo, Parco Tecnologico Padano
Christian Anthon, University of Copenhagen
Loretta Auvil, University of Illinois at Urbana-Champaign
Bouabid Badaoui, Parco Tecnologico Padano
Craig W. Beattie, University of Illinois at Chicago
Christian Bendixen, Aarhus University
Daniel Berman, United States Department of Agriculture
Frank Blecha, Kansas State University
Jonas Blomberg, Uppsala University
Lars Bolund, BGI-Shenzhen
Mirte Bosse, Wageningen University
Sara Botti, Parco Tecnologico Padano
Zhan Bujie, Aarhus University
Megan Bystrom, Iowa State University
Boris Capitanu, University of Illinois at Urbana-Champaign
Denise Carvalho-Silva, European Bioinformatics Institute
Patrick Chardon, Institut National de la Recherche Agronomique
Celine Chen, United States Department of Agriculture
Ryan Cheng, Iowa State University
Sang-Haeng Choi, Korean Research Institute of Bioscience and Biotechnology
William Chow, Wellcome Trust Sanger Institute
Richard C. Clark, Wellcome Trust Sanger Institute
Christopher Clee, Wellcome Trust Sanger Institute
Richard P. M. A. Crooijmans, Wageningen University
Harry D. Dawson, United States Department of Agriculture
Patrice Dehais, Institut National de la Recherche en Agronomique
Fioravante De Sapio, University of Edinburgh
Bert Dibbets, Wageningen University
Nizar Drou, Genome Analysis Centre, Norwich, UK
Zhi-Qiang Du, Iowa State University
Kellye Eversole, Eversole Associates and the Alliance for Animal Genome Research
Joao Fadista, Aarhus University
Susan Fairley, Wellcome Trust Sanger Institute
Thomas Faraut, Institut National de la Recherche en Agronomique
Geoffrey J. Faulkner, University of Edinburgh
Katie E. Fowler, University of Kent at Canterbury - U.K.
Merete Fredholm, University of Copenhagen
Eric Fritz, Iowa State University
James G. R. Gilbert, Wellcome Trust Sanger Institute
Elisabetta Giuffra, Institut National de la Recherche Agronomique
Jan Gorodkin, University of Copenhagen
Darren K. Griffin, University of Kent at Canterbury - U.K.
Jennifer L. Harrow, Wellcome Trust Sanger Institute
Alexander Hayward, Uppsala University
Kerstin Howe, Wellcome Trust Sanger Institute
Zhiliang Hu, Iowa State UniversityFollow
Sean J. Humphray, Wellcome Trust Sanger Institute
Toby Hunt, Wellcome Trust Sanger Institute
Henrik Hornshoj, Aarhus University
Jin-Tae Jeon, Gyeongsang National University
Patric Jern, Uppsala University
Matthew Jones, Wellcome Trust Sanger Institute
Jerzy Jurka, Genetic Information Research Institute
Hiroyuki Kanamori, National Institute of Agrobiological Sciences
Ronan Kapetanovic, University of Edinburgh
Jaebum Kim, Konkuk University
Jae-Hwan Kim, National Institute of Animal Science, South Korea
Kyu-Won Kim, C&K Genomics, Seoul, South Korea
Tae-Hun Kim, National Institute of Animal Science, South Korea
Greger Larson, Durham University
Kyooyeol Lee, Konkuk University
Kyung-Tai Lee, National Institute of Animal Science, South Korea
Richard Leggett, Genome Analysis Centre, Norwich, UK
Harris A. Lewin, University of California, Davis
Yingrui Li, BGI-Shenzhen
Wansheng Liu, The Pennsylvania State University
Jane E. Loveland, Wellcome Trust Sanger Institute
Yao Lu, BGI-Shenzhen
Joan K. Lunney, United States Department of Agriculture
Jian Ma, University of Illinois at Urbana-Champaign
Ole Madsen, Wageningen University
Katherine Mann, United States Department of Agriculture
Lucy Matthews, Wellcome Trust Sanger Institute
Stuart McLaren, Wellcome Trust Sanger Institute
Takeya Morozumi, institute of Japan Association for Techno-innovation in Agriculture, Forestry and Fisheries
Michael P. Murtaugh, University of Minnesota-Twin Cities
Jitendra Narayan, Aberystwyth University
Dinh Truong Nguyen, Konkuk University
Peixiang Ni, Beijing Institute of Genomics of Chinese Academy of Sciences
Song-Jung Oh, Jeju National University, South Korea
Suneel K. Onteru, Iowa State University
Frank Panitz, Aarhus University
Eung-Woo Park, National Institute of Animal Science, South Korea
Hong-Seog Park, Korean Research Institute of Bioscience and Biotechnology
Geraldine Pascal, Institut National de la Recherche en Agronomique
Yogesh Paudel, Wageningen University
Miguel Perez-Enciso, Centre for Research in Agricultural Genomics, Spain
Ricardo Ramirez-Gonzalez, Genome Analysis Centre, Norwich, UK
James M. Reecy, Iowa State UniversityFollow
Sandra Rodriguez-Zas, University of Illinois at Urbana-Champaign
Gary A. Rohrer, United States Department of Agriculture
Lauretta Rund, University of Illinois at Urbana-Champaign
Yongming Sang, Kansas State University
Kyle Schachtschneider, University of Illinois at Urbana-Champaign
Joshua G. Schraiber, University of California - Berkeley
John Schwartz, University of Minnesota - Twin Cities
Linda Scobie, Glasgow Caledonian University
Carol Scott, Wellcome Trust Sanger Institute
Stephen M. Searle, Wellcome Trust Sanger Institute
Bertrand Servin, Institut National de la Recherche en Agronomique
Bruce R. Southey, University of Illinois at Urbana-Champaign
Goran Sperber, Uppsala University
Peter F. Stadler, University of Leipzig
Jonathan V. Sweedler, University of Illinois at Urbana-Champaign
Hakim Tafer, Universitat Leipzig
Bo Thomsen, Aarhus University
Rashmi Wali, Glasgow Caledonian University
Jian Wang, BGI-Shenzhen
Jun Wang, BGI-Shenzhen
Simon White, Wellcome Trust Sanger Institute
Xun Xu, BGI-Shenzhen
Martine Yerle, Institut National de la Recherche Agronomique
Guojie Zhang, BGI-Shenzhen
Jianguo Zhang, Beijing Institute of Genomics of Chinese Academy of Sciences
Jie Zhang, Huazhong Agricultural University
Shuhong Zhao, Huazhong Agricultural University
Jane Rogers, Genome Analysis Centre, Norwich, UK
Carol Churcher, Wellcome Trust Sanger Institute
Lawrence B. Schook, University of Illinois at Urbana-Champaign

Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

2012

Journal or Book Title

Nature

Volume

491

First Page

393

Last Page

398

DOI

10.1038/nature11622

Abstract

For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ~1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.

Comments

This is an article from Nature 491 (2012): 393, doi:10.1038/nature11622. Posted with permission.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf

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