Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

2009

Journal or Book Title

Genetics Selection Evolution

Volume

41

Issue

14

First Page

1

Last Page

9

DOI

10.1186/1297-9686-41-14

Abstract

Background: Identification and culling of replacement gilts with poor skeletal conformation and feet and leg (FL) unsoundness is an approach used to reduce sow culling and mortality rates in breeding stock. Few candidate genes related to soundness traits have been identified in the pig. Methods: In this study, 2066 commercial females were scored for 17 traits describing body conformation and FL structure, and were used for association analyses. Genotyping of 121 SNPs derived from 95 genes was implemented using Sequenom's MassARRAY system. Results: Based on the association results from single trait and principal components using mixed linear model analyses and false discovery rate testing, it was observed that APOE, BMP8, CALCR, COL1A2, COL9A1, DKFZ, FBN1 and VDBP were very highly significantly (P < 0.001) associated with body conformation traits. The genes ALOX5, BMP8, CALCR, OPG, OXTR and WNT16 were very highly significantly (P < 0.001) associated with FL structures, and APOE, CALCR, COL1A2, GNRHR, IHH, MTHFR and WNT16 were highly significantly (P < 0.01) associated with overall leg action. Strong linkage disequilibrium between CALCR and COL1A2 on SSC9 was detected, and haplotype - ACGACC- was highly significantly (P < 0.01) associated with overall leg action and several important FL soundness traits. Conclusion: The present findings provide a comprehensive list of candidate genes for further use in fine mapping and biological functional analyses.

Comments

This is an article from Genetics Selection Evolution 41 (2009): 1, doi:10.1186/1297-9686-41-14. Posted with permission.

Rights

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Copyright Owner

Fan et al

Language

en

File Format

application/pdf

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