Campus Units

Animal Science, Biochemistry, Biophysics and Molecular Biology

Document Type

Article

Publication Version

Published Version

Publication Date

1987

Journal or Book Title

Journal of Animal Science

Volume

64

Issue

2

First Page

394

Last Page

406

DOI

10.2134/jas1987.642394x

Abstract

Disease resistance and immune responsiveness have been traits generally ignored by animal breeders. Recent advances in immunology and molecular biology have opened new avenues towards our understanding of genetic control of these traits. The major histocompatibility gene complex (MHC) appears to play a central role in all immune functions and disease resistance. The need to understand the relationship between immune responsiveness, disease resistance and production traits is discussed in this review. Antagonistic relationships might prevent simultaneous improvement of all of these traits by conventional breeding methods. It is suggested that genetic engineering methods may allow the simultaneous improvement of disease resistance and production traits in domestic animals. Genes of the MHC will be especially good candidates for genetic engineering experiments to improve domestic species.

Comments

This is an article from Journal of Animal Science 64 (1987): 394, doi:10.2134/jas1987.642394x. Posted with permission.

Copyright Owner

American Society of Animal Science

Language

en

File Format

application/pdf

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