Document Type
Article
Publication Date
6-25-2012
Journal or Book Title
BioResearch Open Access
Volume
1
Issue
2
First Page
63
Last Page
68
DOI
10.1089/biores.2012.9902
Abstract
Animal models for cancer therapy are invaluable for preclinical testing of potential cancer treatments; however, therapies tested in such models often fail to translate into clinical settings. Therefore, a better preclinical model for cancer treatment testing is needed. Here we demonstrate that an immunodeficient line of pigs can host and support the growth of xenografted human tumors and has the potential to be an effective animal model for cancer therapy. Wild-type and immunodeficient pigs were injected subcutaneously in the left ear with human melanoma cells (A375SM cells) and in the right ear with human pancreatic carcinoma cells (PANC-1). All immunodeficient pigs developed tumors that were verified by histology and immunohistochemistry. Nonaffected littermates did not develop tumors. Immunodeficient pigs, which do not reject xenografted human tumors, have the potential to become an extremely useful animal model for cancer therapy because of their similarity in size, anatomy, and physiology to humans.
Copyright Owner
Mary Ann Liebert, Inc.
Copyright Date
2012
Language
en
File Format
application/pdf
Recommended Citation
Basel, Matthew T.; Balivada, Sivasai; Beck, Amanda P.; Kerrigan, Maureen A.; Pyle, Maria M.; Dekkers, Jack C. M.; Wyatt, Carol R.; Rowland, Robert R. R.; Anderson, David E.; Bossmann, Stefan H.; and Troyer, Deryl L., "Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs" (2012). Animal Science Publications. 32.
https://lib.dr.iastate.edu/ans_pubs/32
Comments
This is a copy of an article published in the BioResearch Open Access. © 2012 Mary Ann Liebert, Inc.; BioResearch Open Access is available online at: http://online.liebertpub.com.