Document Type

Article

Publication Date

6-25-2012

Journal or Book Title

BioResearch Open Access

Volume

1

Issue

2

First Page

63

Last Page

68

DOI

10.1089/biores.2012.9902

Abstract

Animal models for cancer therapy are invaluable for preclinical testing of potential cancer treatments; however, therapies tested in such models often fail to translate into clinical settings. Therefore, a better preclinical model for cancer treatment testing is needed. Here we demonstrate that an immunodeficient line of pigs can host and support the growth of xenografted human tumors and has the potential to be an effective animal model for cancer therapy. Wild-type and immunodeficient pigs were injected subcutaneously in the left ear with human melanoma cells (A375SM cells) and in the right ear with human pancreatic carcinoma cells (PANC-1). All immunodeficient pigs developed tumors that were verified by histology and immunohistochemistry. Nonaffected littermates did not develop tumors. Immunodeficient pigs, which do not reject xenografted human tumors, have the potential to become an extremely useful animal model for cancer therapy because of their similarity in size, anatomy, and physiology to humans.

Comments

This is a copy of an article published in the BioResearch Open Access. © 2012 Mary Ann Liebert, Inc.; BioResearch Open Access is available online at: http://online.liebertpub.com.

Copyright Owner

Mary Ann Liebert, Inc.

Language

en

File Format

application/pdf

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