Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

2016

Journal or Book Title

BMC Genomics

Volume

17

First Page

812

DOI

10.1186/s12864-016-3147-7

Abstract

Background

Analyses of sequence variants of two distinct and highly inbred chicken lines allowed characterization of genomic variation that may be associated with phenotypic differences between breeds. These lines were the Leghorn, the major contributing breed to commercial white-egg production lines, and the Fayoumi, representative of an outbred indigenous and robust breed. Unique within- and between-line genetic diversity was used to define the genetic differences of the two breeds through the use of variant discovery and functional annotation.

Results

Downstream fixation test (F ST ) analysis and subsequent gene ontology (GO) enrichment analysis elucidated major differences between the two lines. The genes with high F STvalues for both breeds were used to identify enriched gene ontology terms. Over-enriched GO annotations were uncovered for functions indicative of breed-related traits of pathogen resistance and reproductive ability for Fayoumi and Leghorn, respectively.

Conclusions

Variant analysis elucidated GO functions indicative of breed-predominant phenotypes related to genomic variation in the lines, showing a possible link between the genetic variants and breed traits.

Comments

This article is published as Fleming, D. S., J. E. Koltes, E. R. Fritz-Waters, M. F. Rothschild, C. J. Schmidt, C. M. Ashwell, M. E. Persia, J. M. Reecy, and S. J. Lamont. "Single nucleotide variant discovery of highly inbred Leghorn and Fayoumi chicken breeds using pooled whole genome resequencing data reveals insights into phenotype differences." BMC genomics 17 (2016): 812.. doi: 10.1186/s12864-016-3147-7. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

The Authors

Language

en

File Format

application/pdf

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