Campus Units
Animal Science, Mathematics
Document Type
Article
Publication Version
Published Version
Publication Date
2016
Journal or Book Title
BMC Genomics
Volume
17
First Page
891
DOI
10.1186/s12864-016-3235-8
Abstract
Background: Consumers are becoming increasingly conscientious about the nutritional value of their food. Consumption of some fatty acids has been associated with human health traits such as blood pressure and cardiovascular disease. Therefore, it is important to investigate genetic variation in content of fatty acids present in meat. Previously publications reported regions of the cattle genome that are additively associated with variation in fatty acid content. This study evaluated epistatic interactions, which could account for additional genetic variation in fatty acid content.
Results: Epistatic interactions for 44 fatty acid traits in a population of Angus beef cattle were evaluated with EpiSNPmpi. False discovery rate (FDR) was controlled at 5 % and was limited to well-represented genotypic combinations. Epistatic interactions were detected for 37 triacylglyceride (TAG), 36 phospholipid (PL) fatty acid traits, and three weight traits. A total of 6,181, 7,168, and 0 significant epistatic interactions (FDR < 0.05, 50-animals per genotype combination) were associated with Triacylglyceride fatty acids, Phospholipid fatty acids, and weight traits respectively and most were additive-by-additive interactions. A large number of interactions occurred in potential regions of regulatory control along the chromosomes where genes related to fatty acid metabolism reside.
Conclusions: Many fatty acids were associated with epistatic interactions. Despite a large number of significant interactions, there are a limited number of genomic locations that harbored these interactions. While larger population sizes are needed to accurately validate and quantify these epistatic interactions, the current findings point towards additional genetic variance that can be accounted for within these fatty acid traits.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Copyright Owner
The Authors
Copyright Date
2016
Language
en
File Format
application/pdf
Recommended Citation
Kramer, Luke M.; Abdel Ghaffar, M. A.; Koltes, J. E.; Fritz-Waters, E. R.; Mayes, M. S.; Sewell, A. D.; Weeks, N. T.; Garrick, D. J.; Fernando, R. L.; Ma, L.; and Reecy, J. M., "Epistatic interactions associated with fatty acid concentrations of beef from angus sired beef cattle" (2016). Animal Science Publications. 427.
https://lib.dr.iastate.edu/ans_pubs/427
Included in
Agriculture Commons, Beef Science Commons, Biostatistics Commons, Genomics Commons, Molecular, Genetic, and Biochemical Nutrition Commons
Comments
This article is published as Kramer, L. M., MA Abdel Ghaffar, J. E. Koltes, E. R. Fritz-Waters, M. S. Mayes, A. D. Sewell, N. T. Weeks et al. "Epistatic interactions associated with fatty acid concentrations of beef from angus sired beef cattle." BMC genomics 17 (2016): 891. doi: 10.1186/s12864-016-3235-8.