Campus Units

Animal Science

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

4-2018

Journal or Book Title

Reproduction

Volume

155

Issue

4

First Page

R169

Last Page

R181

DOI

10.1530/REP-17-0406

Abstract

Endotoxemia can be caused by obesity, environmental chemical exposure, abiotic stressors, and bacterial infection. Circumstances that deleteriously impact intestinal barrier integrity can induce endotoxemia and controlled experiments have identified negative impacts of lipopolysaccharide (LPS; an endotoxin mimetic) on folliculogenesis, puberty onset, estrus behavior, ovulation, meiotic competence, luteal function and ovarian steroidogenesis. In addition, neonatal LPS exposures have transgenerational female reproductive impacts, raising concern about early life contacts to this endogenous reproductive toxicant. Aims of this review are to identify physiological stressors causing endotoxemia, to highlight potential mechanism(s) by which LPS compromises female reproduction, and identify knowledge gaps regarding how acute and/or metabolic endotoxemia influence(s) female reproduction.

Comments

Disclaimer: this is not the definitive version of record of this article. This manuscript has been accepted for publication in Reproduction, but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at doi: 10.1530/REP-17-0406 (2018).

Copyright Owner

Society for Reproduction and Fertility

Language

en

File Format

application/pdf

Published Version

Share

COinS