Campus Units
Animal Science
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
4-2018
Journal or Book Title
Reproduction
Volume
155
Issue
4
First Page
R169
Last Page
R181
DOI
10.1530/REP-17-0406
Abstract
Endotoxemia can be caused by obesity, environmental chemical exposure, abiotic stressors, and bacterial infection. Circumstances that deleteriously impact intestinal barrier integrity can induce endotoxemia and controlled experiments have identified negative impacts of lipopolysaccharide (LPS; an endotoxin mimetic) on folliculogenesis, puberty onset, estrus behavior, ovulation, meiotic competence, luteal function and ovarian steroidogenesis. In addition, neonatal LPS exposures have transgenerational female reproductive impacts, raising concern about early life contacts to this endogenous reproductive toxicant. Aims of this review are to identify physiological stressors causing endotoxemia, to highlight potential mechanism(s) by which LPS compromises female reproduction, and identify knowledge gaps regarding how acute and/or metabolic endotoxemia influence(s) female reproduction.
Copyright Owner
Society for Reproduction and Fertility
Copyright Date
2018
Language
en
File Format
application/pdf
Recommended Citation
Bidne, K. L.; Dickson, M. J.; Ross, J. W.; Baumgard, L. H.; and Keating, A. F., "Disruption of female reproductive function by endotoxins" (2018). Animal Science Publications. 480.
https://lib.dr.iastate.edu/ans_pubs/480
Included in
Agriculture Commons, Animal Experimentation and Research Commons, Animal Sciences Commons, Cell and Developmental Biology Commons
Comments
Disclaimer: this is not the definitive version of record of this article. This manuscript has been accepted for publication in Reproduction, but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at doi: 10.1530/REP-17-0406 (2018).