Campus Units
Animal Science
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
9-2017
Journal or Book Title
Molecular Reproduction & Development
Volume
84
Issue
9
First Page
934
Last Page
945
DOI
10.1002/mrd.22859
Abstract
Seasonal variations in environmental temperatures impose added stress on domestic species bred for economically important production traits. These heat‐mediated stressors vary on a seasonal, daily, or spatial scale, and negatively impact behavior and reduce feed intake and growth rate, which inevitably lead to reduced herd productivity. The seasonal infertility observed in domestic swine is primarily characterized by depressed reproductive performance, which manifests as delayed puberty onset, reduced farrowing rates, and extended weaning‐to‐estrus intervals. Understanding the effects of heat stress at the organismal, cellular, and molecular level is a prerequisite to identifying mitigation strategies that should reduce the economic burden of compromised reproduction. In this review, we discuss the effect of heat stress on an animal's ability to maintain homeostasis in multiple systems via several hypothalamic‐pituitary‐end organ axes. Additionally, we discuss our understanding of epigenetic programming and how hyperthermia experienced in utero influences industry‐relevant postnatal phenotypes. Further, we highlight the recent recognized mechanisms by which distant tissues and organs may molecularly communicate via extracellular vesicles, a potentially novel mechanism contributing to the heat‐stress response.
Copyright Owner
Wiley Periodicals, Inc.
Copyright Date
2017
Language
en
File Format
application/pdf
Recommended Citation
Ross, Jason W.; Hale, Benjamin J.; Seibert, Jacob T.; Romoser, Matthew R.; Adur, Malavika K.; Keating, Aileen F.; and Baumgard, Lance H., "Physiological mechanisms through which heat stress compromises reproduction in pigs" (2017). Animal Science Publications. 481.
https://lib.dr.iastate.edu/ans_pubs/481
Included in
Agriculture Commons, Animal Sciences Commons, Cell and Developmental Biology Commons, Environmental Sciences Commons, Molecular Genetics Commons, Population Biology Commons
Comments
This is the peer reviewed version of the following article: Ross, Jason W., Benjamin J. Hale, Jacob T. Seibert, Matthew R. Romoser, Malavika K. Adur, Aileen F. Keating, and Lance H. Baumgard. "Physiological mechanisms through which heat stress compromises reproduction in pigs." Molecular reproduction and development 84, no. 9 (2017): 934-945, which has been published in final form at doi: 10.1002/mrd.22859. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.