Campus Units
Animal Science
Document Type
Article
Publication Version
Published Version
Publication Date
2012
Journal or Book Title
Experimental Diabetes Research
Volume
2012
First Page
859395
DOI
10.1155/2012/859395
Abstract
Expansion of intra-abdominal adipose tissue and the accompanying inflammatory response has been put forward as a unifying link between obesity and the development of chronic diseases. However, an apparent sexual dimorphism exists between obesity and chronic disease risk due to differences in the distribution and abundance of adipose tissue. A range of experimental protocols have been employed to demonstrate the role of estrogen in regulating health benefits; however, most studies are confounded by significant differences in body weight and adiposity. Therefore, the purpose of this study was to compare weight-matched obese male and female mice to determine if the sex-dependent health benefits remain when body weight is similar. The development of obesity in female mice receiving a high-fat diet was delayed; however, subsequent comparisons of weight-matched obese mice revealed greater adiposity in obese female mice. Despite excess adiposity and enlarged adipocyte size, obese females remained more glucose tolerant than weight-matched male mice, and this benefit was associated with increased expression of adiponectin and reductions in immune cell infiltration and oxidative stress in adipose tissue. Therefore, the protective benefits of estrogen persist in the obese state and appear to improve the metabolic phenotype of adipose tissue and the individual.
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright Owner
Karen J. Nickelson et al.
Copyright Date
2012
Language
en
File Format
application/pdf
Recommended Citation
Nickelson, Karen J.; Stromsdorfer, Kelly L.; Pickering, R. Taylor; Liu, Tzu-Wen; Ortinau, Laura C.; Keating, Aileen F.; and Perfield, James W. II, "A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice" (2012). Animal Science Publications. 485.
https://lib.dr.iastate.edu/ans_pubs/485
Included in
Animal Experimentation and Research Commons, Animal Sciences Commons, Cellular and Molecular Physiology Commons
Comments
This article is published as Nickelson, Karen J., Kelly L. Stromsdorfer, R. Taylor Pickering, Tzu-Wen Liu, Laura C. Ortinau, Aileen F. Keating, and James W. Perfield. "A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice." Journal of Diabetes Research 2012 (2012): 859395. doi: 10.1155/2012/859395.
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