Campus Units

Animal Science

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

11-15-2010

Journal or Book Title

Toxicology and Applied Pharmacology

Volume

249

Issue

1

First Page

1

Last Page

7

DOI

10.1016/j.taap.2010.08.024

Abstract

Anti-Müllerian hormone (AMH) is produced by granulosa cells in primary to small antral follicles of the adult ovary and helps maintain primordial follicles in a dormant state. The industrial chemical, 4-vinylcyclohexene diepoxide (VCD) causes specific ovotoxicity in primordial and small primary follicles of mice and rats. Previous studies suggest that this ovotoxicity involves acceleration of primordial to primary follicle recruitment via interactions with the Kit/Kit ligand signaling pathway. Because of its accepted role in inhibiting primordial follicle recruitment, the present study was designed to investigate a possible interaction between AMH and VCD-induced ovotoxicity. Protein distribution of AMH was compared in neonatal and adult F344 rat ovaries. AMH protein was visualized by immunofluorescence microscopy in large primary and secondary follicles of the adult ovary, but in small primary follicles in neonatal rat ovaries. In cultured postnatal day (PND) 4 F344 rat ovaries, VCD exposure (30 μM, 2-8d) decreased (P

Comments

This is a manuscript of an artilce published as Mark-Kappeler, Connie J., Nivedita Sen, Aileen F. Keating, I. Glenn Sipes, and Patricia B. Hoyer. "Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity." Toxicology and applied pharmacology 249, no. 1 (2010): 1-7. doi; 10.1016/j.taap.2010.08.024. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

Elsevier Inc.

Language

en

File Format

application/pdf

Published Version

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