Campus Units

Animal Science

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

2011

Journal or Book Title

Experimental Biology and Medicine

Volume

236

Issue

7

First Page

765

Last Page

771

DOI

10.1258/ebm.2011.011051

Abstract

At birth, the mammalian ovary contains a finite number of primordial follicles, which once depleted, cannot be replaced. Xenobiotic exposures can destroy primordial follicles resulting in premature ovarian failure and, consequently, early entry into menopause. A number of chemical classes can induce premature ovarian failure, including environmental, chemotherapeutic and industrial exposures. While our knowledge on the mechanistic events that occur in the ovary with chemical exposures is increasing, our understanding of the ovary's capacity to metabolize such compounds is less established. This review will focus on three chemicals for which information on ovarian metabolism is known: trichloroethylene, 7,12-dimethylbenz[a]anthracene and 4- vinylcyclohexene. The current state of understanding of ovarian bioactivation and detoxification processes for each will be described.

Comments

This is a manuscript of an article published as Bhattacharya, Poulomi, and Aileen F. Keating. "Ovarian metabolism of xenobiotics." Experimental Biology and Medicine 236, no. 7 (2011): 765-771. doi: 10.1258/ebm.2011.011051. Posted with permission.

Copyright Owner

Society for Experimental Biology and Medicine

Language

en

File Format

application/pdf

Published Version

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