Campus Units
Animal Science
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
2011
Journal or Book Title
Experimental Biology and Medicine
Volume
236
Issue
7
First Page
765
Last Page
771
DOI
10.1258/ebm.2011.011051
Abstract
At birth, the mammalian ovary contains a finite number of primordial follicles, which once depleted, cannot be replaced. Xenobiotic exposures can destroy primordial follicles resulting in premature ovarian failure and, consequently, early entry into menopause. A number of chemical classes can induce premature ovarian failure, including environmental, chemotherapeutic and industrial exposures. While our knowledge on the mechanistic events that occur in the ovary with chemical exposures is increasing, our understanding of the ovary's capacity to metabolize such compounds is less established. This review will focus on three chemicals for which information on ovarian metabolism is known: trichloroethylene, 7,12-dimethylbenz[a]anthracene and 4- vinylcyclohexene. The current state of understanding of ovarian bioactivation and detoxification processes for each will be described.
Copyright Owner
Society for Experimental Biology and Medicine
Copyright Date
2011
Language
en
File Format
application/pdf
Recommended Citation
Bhattacharya, Poulomi and Keating, Aileen F., "Ovarian metabolism of xenobiotics" (2011). Animal Science Publications. 492.
https://lib.dr.iastate.edu/ans_pubs/492
Included in
Agriculture Commons, Animal Experimentation and Research Commons, Animal Sciences Commons, Medicine and Health Sciences Commons
Comments
This is a manuscript of an article published as Bhattacharya, Poulomi, and Aileen F. Keating. "Ovarian metabolism of xenobiotics." Experimental Biology and Medicine 236, no. 7 (2011): 765-771. doi: 10.1258/ebm.2011.011051. Posted with permission.