Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

1-18-2019

Journal or Book Title

Genes

Volume

10

Issue

1

First Page

61

DOI

10.3390/genes10010061

Abstract

Newcastle disease virus (NDV) is a highly contagious avian pathogen that poses a tremendous threat to poultry producers in endemic zones due to its epidemic potential. To investigate host genetic resistance to NDV while under the effects of heat stress, a genome-wide association study (GWAS) was performed on Hy-Line Brown layer chickens that were challenged with NDV while under high ambient temperature to identify regions associated with host viral titer, circulating anti-NDV antibody titer, and body weight change. A single nucleotide polymorphism (SNP) on chromosome 1 was associated with viral titer at two days post-infection (dpi), while 30 SNPs spanning a quantitative trait loci (QTL) on chromosome 24 were associated with viral titer at 6 dpi. Immune related genes, such as CAMK1d and CCDC3 on chromosome 1, associated with viral titer at 2 dpi, and TIRAP, ETS1, and KIRREL3, associated with viral titer at 6 dpi, were located in two QTL regions for viral titer that were identified in this study. This study identified genomic regions and candidate genes that are associated with response to NDV during heat stress in Hy-Line Brown layer chickens. Regions identified for viral titer on chromosome 1 and 24, at 2 and 6 dpi, respectively, included several genes that have key roles in regulating the immune response.

Comments

This article is published as Saelao, Perot, Ying Wang, Ganrea Chanthavixay, Rodrigo A. Gallardo, Anna Wolc, Jack Dekkers, Susan J. Lamont, Terra Kelly, and Huaijun Zhou. "Genetics and genomic regions affecting response to newcastle disease virus infection under heat stress in layer chickens." Genes 10, no. 1 (2019): 61. DOI: 10.3390/genes10010061. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

The Author(s)

Language

en

File Format

application/pdf

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