Campus Units
Animal Science
Document Type
Article
Publication Version
Published Version
Publication Date
7-31-2017
Journal or Book Title
PLoS ONE
Volume
12
Issue
7
First Page
e0181900
DOI
10.1371/journal.pone.0181900
Abstract
The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Owner
Jastrebski et al.
Copyright Date
2017
Language
en
File Format
application/pdf
Recommended Citation
Jastrebski, Sara F.; Lamont, Susan J.; and Schmidt, Carl J., "Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis" (2017). Animal Science Publications. 577.
https://lib.dr.iastate.edu/ans_pubs/577
Comments
This article is published as Jastrebski, Sara F., Susan J. Lamont, and Carl J. Schmidt. "Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis." PLoS ONE 12, no. 7 (2017): e0181900. DOI: 10.1371/journal.pone.0181900. Posted with permission.