Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

7-31-2017

Journal or Book Title

PLoS ONE

Volume

12

Issue

7

First Page

e0181900

DOI

10.1371/journal.pone.0181900

Abstract

The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.

Comments

This article is published as Jastrebski, Sara F., Susan J. Lamont, and Carl J. Schmidt. "Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis." PLoS ONE 12, no. 7 (2017): e0181900. DOI: 10.1371/journal.pone.0181900. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

Jastrebski et al.

Language

en

File Format

application/pdf

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