Title
Immune response gene expression in spleens of diverse chicken lines fed dietary immunomodulators
Campus Units
Animal Science, Biomedical Sciences, Veterinary Microbiology and Preventive Medicine, Veterinary Pathology
Document Type
Article
Publication Version
Published Version
Publication Date
5-1-2011
Journal or Book Title
Poultry Science
Volume
90
Issue
5
First Page
1009
Last Page
1013
DOI
10.3382/ps.2010-01235
Abstract
Vaccines, antibiotics, and other therapeutic agents used to combat disease in poultry generate recurring costs and the potential of residues in poultry products. Enhancing the immune response using alternative approaches such as selection for increased disease resistance or dietary immunomodulation may be effective additions to the portfolio of strategies the industry applies in poultry health management. The objective of this study was to characterize the effects of dietary supplementation with 3 immunomodulators [ascorbic acid, 1,3–1,6 β-glucans from baker's yeast, and corticosterone] on cytokine gene expression in the spleen of 3 distinct genetic lines of chickens. Relative mRNA expression levels were determined using quantitative reverse transcriptase PCR for IL-1β, IL-2, inducible nitric oxide synthase, and toll-like receptors 4 and 15, all of which play important roles in chicken immune function. Expression data were analyzed by mixed model analysis. The only significant effect detected was sex effect (P < 0.04) on expression of IL-1β. The present findings suggest the need for further investigations into the effects of dietary immunomodulators on cytokine gene expression in chickens so as to generate a better understanding of the immunomodulation process.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Copyright Owner
Poultry Science Association Inc.
Copyright Date
2011
Language
en
File Format
application/pdf
Recommended Citation
Kumar, S.; Ciraci, C.; Redmond, S. B.; Chuammitri, P.; Andreasen, Claire B.; Palić, D.; and Lamont, Susan J., "Immune response gene expression in spleens of diverse chicken lines fed dietary immunomodulators" (2011). Animal Science Publications. 610.
https://lib.dr.iastate.edu/ans_pubs/610
Included in
Genetics Commons, Poultry or Avian Science Commons, Veterinary Pathology and Pathobiology Commons, Veterinary Preventive Medicine, Epidemiology, and Public Health Commons
Comments
This article is published as Kumar, S., C. Ciraci, S. B. Redmond, P. Chuammitri, C. B. Andreasen, D. Palić, and S. J. Lamont. "Immune response gene expression in spleens of diverse chicken lines fed dietary immunomodulators." Poultry Science 90, no. 5 (2011): 1009-1013. DOI: 10.3382/ps.2010-01235. Posted with permission.