Campus Units

Animal Science, Biomedical Sciences, Veterinary Microbiology and Preventive Medicine, Veterinary Pathology

Document Type

Article

Publication Version

Published Version

Publication Date

5-1-2011

Journal or Book Title

Poultry Science

Volume

90

Issue

5

First Page

1009

Last Page

1013

DOI

10.3382/ps.2010-01235

Abstract

Vaccines, antibiotics, and other therapeutic agents used to combat disease in poultry generate recurring costs and the potential of residues in poultry products. Enhancing the immune response using alternative approaches such as selection for increased disease resistance or dietary immunomodulation may be effective additions to the portfolio of strategies the industry applies in poultry health management. The objective of this study was to characterize the effects of dietary supplementation with 3 immunomodulators [ascorbic acid, 1,3–1,6 β-glucans from baker's yeast, and corticosterone] on cytokine gene expression in the spleen of 3 distinct genetic lines of chickens. Relative mRNA expression levels were determined using quantitative reverse transcriptase PCR for IL-1β, IL-2, inducible nitric oxide synthase, and toll-like receptors 4 and 15, all of which play important roles in chicken immune function. Expression data were analyzed by mixed model analysis. The only significant effect detected was sex effect (P < 0.04) on expression of IL-1β. The present findings suggest the need for further investigations into the effects of dietary immunomodulators on cytokine gene expression in chickens so as to generate a better understanding of the immunomodulation process.

Comments

This article is published as Kumar, S., C. Ciraci, S. B. Redmond, P. Chuammitri, C. B. Andreasen, D. Palić, and S. J. Lamont. "Immune response gene expression in spleens of diverse chicken lines fed dietary immunomodulators." Poultry Science 90, no. 5 (2011): 1009-1013. DOI: 10.3382/ps.2010-01235. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

Poultry Science Association Inc.

Language

en

File Format

application/pdf

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