Document Type

Article

Publication Version

Published Version

Publication Date

10-28-2013

Journal or Book Title

International Journal of Environmental Research and Public Health

Volume

10

Issue

11

First Page

5459

Last Page

5469

DOI

10.3390/ijerph10115459

Abstract

Abstract: The antimicrobial effect of a novel flavonoid (7-O-butylnaringenin) on Helicobacter pylori 26695, 51, and SS1 strains and its inhibitory effect on the urease activity of the strains were evaluated and compared with those of several natural flavonoids. First, various flavonoids were screened for antimicrobial activities using the paper disc diffusion method. Hesperetin and naringenin showed the strongest antimicrobial effects among the natural flavonoids tested, and thus hesperetin and naringenin were selected for comparison with 7-O-butylnaringenin. The antimicrobial effect of 7-O-butylnaringenin was greater than that of the hesperetin and naringenin. H. pylori 51 was more sensitive to 7-O-butylnaringenin (2 log reduction of colony forming units, p < 0.05) than the other two strains at 200 μM. 7-O-Butylnaringenin also showed the highest inhibitory effect against urease activity of H. pylori. Morphological changes of H. pylori 26695 treated with these flavonoids indicated that both hesperetin and 7-O-butylnaringenin at 200 μM damaged the cell membranes.

Comments

This article is from International Journal of Environmental Research and Public Health 10 (2013): 5459–5469, doi:10.3390/ijerph10115459. Posted with permission.

Rights

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Copyright Owner

The authors

Language

en

File Format

application/pdf

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