Document Type
Article
Publication Version
Published Version
Publication Date
2014
Journal or Book Title
BioMed Research International
Volume
2014
First Page
598612
DOI
10.1155/2014/598612
Abstract
This study was conducted to determine the effects of dietary cholesterol (CHO) and cholesterol oxidation products (COPs) on the induction of pathological lesions in rabbit liver tissues. Liver lesions were induced only when the levels of CHO and COPs in the diet were very high. The amount of CHO measured in the liver increased when dietary CHO was increased; by comparison, dietary COPs affected liver CHO amounts to a lesser extent. The TBARS (thiobarbituric acid reactive substances) value measured for the liver samples also increased when dietary CHO and COP levels were elevated, and the TBARS value was more strongly affected by the amount of COPs in the diet than by the amount of CHO. At 6 and 12 weeks, COP levels were the highest in the group that received 1.2 g CHO + 0.8 g COPs, followed by the 0.5 g CHO + 0.5 g COPs and 1.6 g CHO + 0.4 g COPs groups; the control (0 g) group showed the lowest COP levels among all groups. In this study, we found that not only dietary CHO but also COPs were involved in hypercholesterolemia induced liver lesions when the amount of CHO and COPs was high.
Rights
Copyright © 2014 Sun Jin Hur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright Owner
Sun Jin Hur et al.
Copyright Date
2014
Language
en
File Format
application/pdf
Recommended Citation
Hur, Sun Jin; Nam, Ki Chang; Min, Byongrok; Du, Min; Seo, Kwon Il; and Ahn, Dong U., "Effects of Dietary Cholesterol and Its Oxidation Products on Pathological Lesions and Cholesterol and Lipid Oxidation in the Rabbit Liver" (2014). Animal Science Publications. 65.
https://lib.dr.iastate.edu/ans_pubs/65
Comments
This article is from BioMed Research International 2014 (2014): 598612, doi:10.1155/2014/598612. Posted with permission