Campus Units
Animal Science
Document Type
Article
Publication Version
Published Version
Publication Date
2014
Journal or Book Title
European Review for Medical and Pharmacological Sciences
Volume
18
Issue
16
First Page
2393
Last Page
2399
Abstract
OBJECTIVES: At present it is known that the adjustment of the anticancer therapy to the circadian rhythms in tissues reduces the toxicity of the treatment. Chronotherapy also increases the efficacy of the anticancer treatment, which has been proved for many drugs. Sunitinib is a tyrosine kinase inhibitor, which is broadly used for the treatment of numerous cancers. The aim of the study was a comparison of the concentrations and pharmacokinetics of sunitinib after a single administration to rabbits at 08:00 (control group) and 20:00. Additionally, the effect of sunitinib on glucose levels was investigated.
MATERIALS AND METHODS: The research was carried out on two groups of rabbits: I08:00, a group with the drug administered at 08:00 (n=8) and II20:00, a group with the drug administered at 20:00 (n=8). The rabbits were treated with sunitinib at an oral dose of 25 mg. Plasma concentrations of sunitinib and its metabolite (SU12662) were measured with a validated HPLC method with UV detection.
RESULTS: The comparison of the sunitinib Cmax and AUC0-t in the group with sunitinib administered at 20:00 with the control group gave the ratios of 2.20 (90% confidence interval (CI) (2.17; 2.22) and 1.64 (1.61; 1.68), respectively. Statistically significant differences between the groups under analysis were revealed for Cmax (p < 0.0001), AUC0-t (p = 0.0079), AUC0-∞ (p = 0.0149), and tmax (p = 0.0085). The mean glycemia drop was higher in group I08:00. than in group II20:00 (22.7% vs. 14.3%; p = 0.0622). The glycemia values returned to the initial values in 24 h after the administration of the drug in both groups.
CONCLUSIONS: The research proved a significant influence of the time-of-day administration on the pharmacokinetics of sunitinib.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Copyright Owner
European Review for Medical and Pharmacological Sciences
Copyright Date
2014
Language
en
File Format
application/pdf
Recommended Citation
Szałek, E.; Karbownik, A.; Sobańska, K.; Połom, W.; Grabowski, T.; Wolc, Anna; Matuszewski, M.; and Grześkowiak, E., "The influence of the time-of-day administration of the drug on the pharmacokinetics of sunitinib in rabbits" (2014). Animal Science Publications. 656.
https://lib.dr.iastate.edu/ans_pubs/656
Included in
Animal Experimentation and Research Commons, Animal Sciences Commons, Medicinal Chemistry and Pharmaceutics Commons
Comments
This article is published as Szałek, E., A. Karbownik, K. Sobańska, W. Połom, T. Grabowski, A. Wolc, M. Matuszewski, and E. Grześkowiak. "The influence of the time-of-day administration of the drug on the pharmacokinetics of sunitinib in rabbits." Eur Rev Med Pharmacol Sci 18, no. 16 (2014): 2393-2399.