Title
Identifying the genetic basis for resistance to avian influenza in commercial egg layer chickens
Campus Units
Animal Science
Document Type
Article
Publication Version
Published Version
Publication Date
2018
Journal or Book Title
Animal
Volume
12
Issue
7
First Page
1363
Last Page
1371
DOI
10.1017/S1751731117002889
Abstract
Two highly pathogenic avian influenza (HPAI) outbreaks have affected commercial egg production flocks in the American continent in recent years; a H7N3 outbreak in Mexico in 2012 that caused 70% to 85% mortality and a H5N2 outbreak in the United States in 2015 with over 99% mortality. Blood samples were obtained from survivors of each outbreak and from age and genetics matched non-affected controls. A total of 485 individuals (survivors and controls) were genotyped with a 600 k single nucleotide polymorphism (SNP) array to detect genomic regions that influenced the outcome of highly pathogenic influenza infection in the two outbreaks. A total of 420458 high quality, segregating SNPs were identified across all samples. Genetic differences between survivors and controls were analyzed using a logistic model, mixed models and a Bayesian variable selection approach. Several genomic regions potentially associated with resistance to HPAI were identified, after performing multidimensional scaling and adjustment for multiple testing. Analysis conducted within each outbreak identified different genomic regions for resistance to the two virus strains. The strongest signals for the Iowa H5N2 survivor samples were detected on chromosomes 1, 7, 9 and 15. Positional candidate genes were mainly coding for plasma membrane proteins with receptor activity and were also involved in immune response. Three regions with the strongest signal for the Mexico H7N3 samples were located on chromosomes 1 and 5. Neuronal cell surface, signal transduction and immune response proteins coding genes were located in the close proximity of these regions.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Copyright Owner
The Animal Consortium
Copyright Date
2017
Language
en
File Format
application/pdf
Recommended Citation
Drobik-Czwarno, W.; Wolc, Anna; Fulton, J. E.; Arango, J.; Jankowski, T.; O'Sullivan, N. P.; and Dekkers, Jack C. M., "Identifying the genetic basis for resistance to avian influenza in commercial egg layer chickens" (2018). Animal Science Publications. 661.
https://lib.dr.iastate.edu/ans_pubs/661
Included in
Genetics and Genomics Commons, Immunology and Infectious Disease Commons, Poultry or Avian Science Commons
Comments
This article is published as Drobik-Czwarno, W., A. Wolc, J. E. Fulton, J. Arango, T. Jankowski, N. P. O’Sullivan, and J. C. M. Dekkers. "Identifying the genetic basis for resistance to avian influenza in commercial egg layer chickens." Animal 12, no. 7 (2018): 1363-1371. doi: 10.1017/S1751731117002889.