Campus Units
Animal Science
Document Type
Article
Publication Version
Published Version
Publication Date
7-1-2003
Journal or Book Title
Poultry Science
Volume
82
Issue
7
First Page
1118
Last Page
1126
DOI
10.1093/ps/82.7.1118
Abstract
The chicken B-cell marker (ChB6), caspase-1, inhibitor of apoptosis protein-1 (IAP-1), interleukin-15 receptor alpha-chain (IL-15Ralpha), interleukin-2 receptor gamma-chain (IL-2Rgamma), and immunoglobulin supfamily gene (ZOV3), as physiological candidate genes for chicken immune response, were selected to investigate associations with antibody kinetics to SRBC and killed B. abortus. An F2 population was derived from mating highly inbred (>99%) males of two MHC-congenic Fayoumi lines (named M5.1 and M15.2) with G-B1 Leghorn hens. Antibody response to SRBC and B. abortus after immunization at 19 and 22 wk were measured. Secondary phase parameters of maximum titers (Ymax) and time required to achieve Ymax (Tmax) were estimated from postsecondary titers by using a nonlinear regression model. The DNA polymorphisms of six genes were identified, and associations of single nucleotide polymorphisms (SNP) in the six genes with antibody response parameters were analyzed. Significant main effects of the gene polymorphisms were mostly found in the lineage of the M5.1 grandsire and primarily on antibody response to B. abortus. There was general agreement of allelic effect within antibody parameters among genes. These results suggest that the SNP characterized in the study may serve as markers for genetic enhancement of humoral immune capacity in the chicken.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Copyright Owner
Poultry Science Association Inc.
Copyright Date
2003
Language
en
File Format
application/pdf
Recommended Citation
Zhou, H. and Lamont, Susan J., "Associations of six candidate genes with antibody response kinetics in hens" (2003). Animal Science Publications. 666.
https://lib.dr.iastate.edu/ans_pubs/666
Comments
This article is published as Zhou, H., and S. J. Lamont. "Associations of six candidate genes with antibody response kinetics in hens." Poultry Science 82, no. 7 (2003): 1118-1126. DOI: 10.1093/ps/82.7.1118. Posted with permission.