Campus Units
Animal Science
Document Type
Article
Publication Version
Published Version
Publication Date
6-27-2012
Journal or Book Title
PLOS Currents Muscular Dystrophy
DOI
10.1371/4f84a944d8930
Abstract
Dystrophin deficiency leads to increased proteasome activity in skeletal muscle. Previous observations suggest short-term inhibition of the proteasome restores dystrophin expression. Contrary to our hypothesis, eight days of MG-132 administration to mdx mice increased susceptibility to contraction induced injury and Evan’s blue dye penetration compared to controls. Following six weeks of MG-132 administration muscle function was similar to control animals. These data suggest that proteasome inhibition does not reduce the severity of muscle dysfunction caused by dystrophin-deficiency.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Owner
The Authors
Copyright Date
2012
Language
en
File Format
application/pdf
Recommended Citation
Selsby, Joshua; Morris, Carl; Morris, Linda; and Sweeney, Lee, "A proteasome inhibitor fails to attenuate dystrophic pathology in mdx mice" (2012). Animal Science Publications. 701.
https://lib.dr.iastate.edu/ans_pubs/701
Included in
Animal Experimentation and Research Commons, Animal Sciences Commons, Musculoskeletal Diseases Commons
Comments
This article is published as Selsby J, Morris C, Morris L, Sweeney L. A proteasome inhibitor fails to attenuate dystrophic pathology in mdx mice. PLOS Currents Muscular Dystrophy. 2012 Jun 27 . Edition 1. doi: 10.1371/4f84a944d8930. Posted with permission.