Journal or Book Title
PLOS Currents Muscular Dystrophy
Dystrophin deficiency leads to increased proteasome activity in skeletal muscle. Previous observations suggest short-term inhibition of the proteasome restores dystrophin expression. Contrary to our hypothesis, eight days of MG-132 administration to mdx mice increased susceptibility to contraction induced injury and Evan’s blue dye penetration compared to controls. Following six weeks of MG-132 administration muscle function was similar to control animals. These data suggest that proteasome inhibition does not reduce the severity of muscle dysfunction caused by dystrophin-deficiency.
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Selsby, Joshua; Morris, Carl; Morris, Linda; and Sweeney, Lee, "A proteasome inhibitor fails to attenuate dystrophic pathology in mdx mice" (2012). Animal Science Publications. 701.