Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

6-27-2012

Journal or Book Title

PLOS Currents Muscular Dystrophy

DOI

10.1371/4f84a944d8930

Abstract

Dystrophin deficiency leads to increased proteasome activity in skeletal muscle. Previous observations suggest short-term inhibition of the proteasome restores dystrophin expression. Contrary to our hypothesis, eight days of MG-132 administration to mdx mice increased susceptibility to contraction induced injury and Evan’s blue dye penetration compared to controls. Following six weeks of MG-132 administration muscle function was similar to control animals. These data suggest that proteasome inhibition does not reduce the severity of muscle dysfunction caused by dystrophin-deficiency.

Comments

This article is published as Selsby J, Morris C, Morris L, Sweeney L. A proteasome inhibitor fails to attenuate dystrophic pathology in mdx mice. PLOS Currents Muscular Dystrophy. 2012 Jun 27 . Edition 1. doi: 10.1371/4f84a944d8930. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright Owner

The Authors

Language

en

File Format

application/pdf

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