Campus Units
Animal Science
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
9-2013
Journal or Book Title
Journal of Applied Physiology
Volume
115
Issue
5
First Page
660
Last Page
666
DOI
10.1152/japplphysiol.00252.2013
Abstract
Dystrophin-deficient muscles suffer from free radical injury, mitochondrial dysfunction, apoptosis, and inflammation, among other pathologies, which contribute to muscle fiber injury and loss leading to wheel chair confinement and death in the patient. For some time it has been appreciated that endurance training has the potential to counter many of these contributing factors. Correspondingly, numerous investigations have shown improvements in limb muscle function following endurance training in mdx mice. However, the effect of long-term volitional wheel running on diaphragm and cardiac function is largely unknown. Our purpose was to determine the extent to which long-term endurance exercise affected dystrophic limb, diaphragm and cardiac function. Following one year of volitional wheel running diaphragm specific tension was reduced by 60% (p
Copyright Owner
American Physiological Society
Copyright Date
2013
Language
en
File Format
application/pdf
Recommended Citation
Selsby, Joshua T.; Acosta, Pedro; Sleeper, Meg M.; Barton, Elisabeth R.; and Sweeney, H. Lee, "Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse" (2013). Animal Science Publications. 703.
https://lib.dr.iastate.edu/ans_pubs/703
Included in
Animal Experimentation and Research Commons, Animal Sciences Commons, Cardiology Commons, Exercise Physiology Commons, Musculoskeletal Diseases Commons
Comments
This is a manuscript of an article published as Selsby, Joshua T., Pedro Acosta, Meg M. Sleeper, Elisabeth R. Barton, and H. Lee Sweeney. "Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse." Journal of Applied Physiology 115, no. 5 (2013): 660-666. doi: 10.1152/japplphysiol.00252.2013. Posted with permission.