Campus Units
Animal Science
Document Type
Article
Publication Version
Published Version
Publication Date
8-1-2001
Journal or Book Title
Poultry Science
Volume
80
Issue
8
First Page
1064
Last Page
1072
DOI
10.1093/ps/80.8.1064
Abstract
Genetic improvement for resistance to Marek's Disease (MD) in chickens continues to be of interest to the poultry industry. The aims of this study were to identify effects of the MHC on the molecular level and of avian leukosis virus (ALV) resistance status on MD mortality in two noninbred White Leghorn chicken lines that differ in B blood group type. Previously, within each of the chicken lines, sublines had been selected for resistance or susceptibility to ALV infection with Subgroups A and B. In this study, F2 offspring, obtained by crossing the two ALV-resistant or the two ALV-susceptible sublines, were tested for MD mortality after contact exposure at 1 d of age. Reciprocal matings were made in the grandparental generation. The MD mortality percentages, in an observation period of 17 wk, of F2 offspring from two hatches were 82.63 and 92.35%, respectively. Survival analysis (Cox model) was applied to assess the risk of dying from MD. No differences in MD mortality risk profiles were found between ALV-resistant and ALV-susceptible F2 offspring. Within ALV-susceptible F2 offspring, however, a reciprocal mating effect was observed in both hatches. The MHC Class I, II, and IV restriction fragment length polymorphism (RFLP) analyses were carried out on birds of the first hatch. Although two of 11 MHC class IV RFLP bands displayed a significant effect, in general, a strong association of MHC and MD mortality was not detectable.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Copyright Owner
Poultry Science Association Inc.
Copyright Date
2001
Language
en
File Format
application/pdf
Recommended Citation
Weigend, S.; Matthes, S.; Sölkner, J.; and Lamont, Susan J., "Resistance to Marek’s disease virus in white Leghorn chickens: effects of avian leukosis virus infection genotype, reciprocal mating, and major histocompatibility complex" (2001). Animal Science Publications. 712.
https://lib.dr.iastate.edu/ans_pubs/712
Comments
This article is published as Weigend, S., S. Matthes, J. Sölkner, and S. J. Lamont. "Resistance to Marek's disease virus in White Leghorn chickens: Effects of avian leukosis virus infection genotype, reciprocal mating, and major histocompatibility complex." Poultry Science 80, no. 8 (2001): 1064-1072. DOI: 10.1093/ps/80.8.1064. Posted with permission.