Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

9-1-1997

Journal or Book Title

Poultry Science

Volume

76

Issue

9

First Page

1248

Last Page

1255

DOI

10.1093/ps/76.9.1248

Abstract

To evaluate the kinetics of immune response to vaccines in chickens, antibody response curves were approximated to the observed antibody ratios by using a nonlinear regression function. New parameters, the curve maximum (ymax) and the time of the maximum (tmax), were calculated. The method was applied to analyze the kinetics of the serum antibody response to Mycoplasma gallisepticum (MG) and Pasteurella multocida (PM) vaccines in White Leghorn lines selected, in replicate, for 10 generations for high (High) and low (Low) multitrait immune response. Chicks were immunized at 6 wk of age with both vaccines. Serum antibody levels were analyzed before (0) and 1, 2, 3, 4, 5, 12, and 21 wk postvaccination (wpv). The High lines displayed a significantly higher response than Low to both MG and PM. The difference in ymax between High and Low lines was 3.25-fold for PM response and 1.5-fold for MG response. Low lines had a significantly (P < 0.05) later tmax than High lines to MG, but not to PM. There was a significant (P < 0.05) positive correlation between the antibody responses to MG and PM, in High lines for the antibody ratios 0, 3, and 21 wpv and in Low lines for 0, 12, and 21 wpv. The ymax and tmax of antibody responses to the two vaccines were not correlated. The results on the kinetic differences of the antibody responses to MG and PM suggest that the kinetics and persistence of antibody reaction have different genetic regulation in response to each vaccine.

Comments

This article is published as Weigend, S., N. Mielenz, and S. J. Lamont. "Application of a nonlinear regression function to evaluate the kinetics of antibody response to vaccines in chicken lines divergently selected for multitrait immune response." Poultry Science 76, no. 9 (1997): 1248-1255. DOI: 10.1093/ps/76.9.1248. Posted with permission.

Copyright Owner

Poultry Science Association Inc.

Language

en

File Format

application/pdf

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