Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

4-1-1998

Journal or Book Title

Poultry Science

Volume

77

Issue

4

First Page

538

Last Page

541

DOI

10.1093/ps/77.4.538

Abstract

Although the influence of the chicken classical MHC in resistance to many diseases is well established, the role of the recently identified, genetically independent, MHC-like region known as Rfp-Y is unclear. The objectives of this study were to analyze the frequencies of DNA polymorphisms of the Rfp-Y region in White Leghorn lines, which were divergently selected in replicate for multitrait immunocompetence, and to determine the association of these polymorphisms with Marek's disease (MD) resistance. Chicks, either with or without herpes virus of turkey (HVT) vaccination, were challenged with 500 ffu of a very virulent Marek's disease virus (Md5) at 2 d of age. The MD-related data were collected for 10 wk. PvuII-digested genomic DNA was hybridized with an Rfp-Y region-specific probe, 18.1. Three Rfp-Y polymorphisms were observed. The frequency of one Rfp-Y polymorphism was significantly different between divergently selected multitrait immunocompetence lines in one replicate only; therefore, the impact of multitrait immunocompetence selection on Rfp-Y polymorphisms is inconclusive. The PvuII defined Rfp-Y region polymorphisms had no association with either innate or vaccine-induced MD resistance to Md5 virus challenge.

Comments

This article is published as Lakshmanan, N., and S. J. Lamont. "Rfp-Y region polymorphism and Marek's disease resistance in multitrait immunocompetence-selected chicken lines." Poultry Science 77, no. 4 (1998): 538-541. DOI: 10.1093/ps/77.4.538. Posted with permission.

Copyright Owner

Poultry Science Association Inc.

Language

en

File Format

application/pdf

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