Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

1-1-1993

Journal or Book Title

Poultry Science

Volume

72

Issue

1

First Page

76

Last Page

81

DOI

10.3382/ps.0720076

Abstract

Level of humoral immune response to GAT has been associated with the MHC of chickens. Matings between two unrelated lines of chickens with low antibody response to GAT (G-B1 and S1 Line B19L) resulted in progeny that were higher responders to GAT challenge (P < .05) than either of the parental lines. Progeny of matings between two related sublines that are low responders to GAT (S1 Lines B19L and B1L) had antibody responses to GAT that were not higher than the parental lines. Progeny of the between-line cross were backcrossed to S1 B19L and G-B1 (B13) parental lines, as well as mated inter se. These matings produced F2 progeny whose GAT response was significantly associated (P < .05) with their MHC (Ea-B) type. The progeny were of three MHC types (B19B19, B19B13, and B13B13) that bound 66.6, 71.9, and 4.6%, respectively, of the GAT in a radioimmunoassay. The results from these matings suggest that MHC or MHC-linked genes, as well as genes not linked to the MHC, contribute to control of humoral immune response to GAT in the lines of chicken tested.

Comments

This article is published as Steadham, E. M., and S. J. Lamont. "Gene complementation in biological crosses for humoral immune response to glutamic acid-alanine-tyrosine." Poultry Science 72, no. 1 (1993): 76-81. DOI: 10.3382/ps.0720076. Posted with permission.

Copyright Owner

Poultry Science Association Inc.

Language

en

File Format

application/pdf

Share

COinS