Campus Units

Animal Science, Biochemistry, Biophysics and Molecular Biology, Roy J. Carver Department of

Document Type

Article

Publication Version

Published Version

Publication Date

5-1-1987

Journal or Book Title

Poultry Science

Volume

66

Issue

5

First Page

8198

Last Page

824

DOI

10.3382/ps.0660819

Abstract

New technologies are enabling researchers to conduct analysis of the molecular structure of the genes and gene products of the major histocompatibility complex (MHC). Two of these new technologies are the production of monoclonal antibodies by hybridomas and analysis of deoxyribonucleic acid (DNA) by restriction fragment length polymorphisms (RFLP) on Southern blots. Monoclonal antibodies, because of their exquisite specificity, can be used to isolate purified MHC antigens for further study. The RFLP analysis can be used to examine differences in the MHC at the DNA level. This paper describes the two aforementioned technologies and their application to molecular analysis of the chicken MHC.

Comments

This article is published as Lamont, S. J., C. M. Warner, and A. W. Nordskog. "Molecular analysis of the chicken major histocompatibility complex gene and gene products." Poultry Science 66, no. 5 (1987): 819-824. DOI: 10.3382/ps.0660819. Posted with permission.

Copyright Owner

Poultry Science Association Inc.

Language

en

File Format

application/pdf

Share

COinS