Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

11-1-1991

Journal or Book Title

Poultry Science

Volume

70

Issue

10

First Page

2371

Last Page

2374

DOI

10.3382/ps.0702371

Abstract

Measurement of a humoral anamnestic response is a common procedure used to evaluate immunological competence. The purposes of the present study were to determine the optimum time period between primary and secondary immunizations needed to obtain the maximum antibody titer and to determine whether this interval differs with the age of the chicken or with the type of inducing antigen. The anamnestic responses of birds of two ages to a T-cell–dependent antigen (SRBC) and to a T-cell–independent antigen (Brucella abortus, BA) were evaluated. Birds of 4 wk or 6 mo of age were injected i.v. with either BA or SRBC, and a secondary injection was given 2, 4, 6, or 8 wk later. Agglutination titers for total and mercaptoethanol (ME)-resistant antibodies were determined from serum samples collected at 3, 6, and 9 days postsecondary immunization. Generally, titers were highest at 6 days postsecondary immunization. For both antigens, the chick total antibody levels at Day 6 postsecondary immunization were higher at 4-, 6-, and 8-wk immunization intervals than at 2-wk intervals; adult titers were independent of immunization interval. There was an interaction between age of birds and type of antigen.

Comments

This article is published as Munns, Paula L., and S. J. Lamont. "Research Note: Effects of Age and Immunization Interval on the Anamnestic Response to T-Cell–Dependent and T-Cell–Independent Antigens in Chickens." Poultry Science 70, no. 11 (1991): 2371-2374. DOI: 10.3382/ps.0702371. Posted with permission.

Copyright Owner

Poultry Science Association Inc.

Language

en

File Format

application/pdf

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