Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

1998

Journal or Book Title

OIE Revue Scientifique et Technique (International Office of Epizootics)

Volume

17

Issue

1

First Page

128

Last Page

142

DOI

10.20506/rst.17.1.1090

Abstract

The chicken major histocompatibility complex (MHC), or B complex, consists of several clusters of highly polymorphic genes, some of which are associated with disease resistance. The class I and class II antigens resemble their mammalian counterparts in the encoded protein structure. The class IV region encodes the B blood group antigens, which are readily identified by serological blood-typing. The class III region appears to be divided in chickens, with some elements that are MHC-linked and others that map elsewhere. In addition the Rfp-Y system, which bears a strong similarity to the MHC, maps to the opposite side of the nucleolar organiser region on the same microchromosome as the MHC. Each class of MHC genes is a potential candidate for a role in disease resistance. The MHC genes show associations with response to diseases as diverse as virally induced neoplasia, bacterial, parasitic and auto-immune diseases.

Comments

This article is published as Lamont, Susan J. "The chicken major histocompatibility complex and disease." OIE Revue Scientifique et Technique 17, no. 1 (1998): 128-142. DOI: 10.20506/rst.17.1.1090. Posted with permission.

Copyright Owner

OIE

Language

en

File Format

application/pdf

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