Campus Units

Animal Science

Document Type

Article

Publication Version

Published Version

Publication Date

11-2020

Journal or Book Title

Food Science of Animal Resources

Volume

40

Issue

6

First Page

1001

Last Page

1013

DOI

10.5851/kosfa.2020.e71

Abstract

The formation of biofilms on the enamel surface of teeth by Streptococcus mutans is an important step in dental plaque formation, demineralization, and early caries because the biofilm is where other bacteria involved in dental caries attach, grow, and proliferate. The objectives of this study were to determine the effect of phosvitin (PSV) on the biofilm formation, exopolysaccharides (EPS) production, adherence activity of S. mutans, and the expression of genes related to the compounds essential for biofilm formation (quorum-sensing inducers and components of biofilm matrix) by S. mutans. PSV significantly reduced the biofilm-forming activity of S. mutans and increased the degradation of preformed biofilms by S. mutans. PSV inhibited the adherence activity of S. mutans by 31.9%–33.6%, and the production of EPS by 62%–65% depending upon the strains and the amount of PSV added. The expressions of genes regulating the production of EPS and the quorum-sensing-inducers (gtfA, gtfD, ftf, relA, vicR, brpA, and comDE) in all S. mutans strains were down-regulated by PSV, but gtfB was down-regulated only in S. mutans KCTC 5316. Therefore, the anti-biofilm-forming activity of PSV was accomplished through the inhibition of biofilm formation, adherence activity, and the production of quorum-sensing inducers and EPS by S. mutans.

Comments

This article is published as Kim, Hyeon Joong, Jae Hoon Lee, Dong Uk Ahn, and Hyun-Dong Paik. "Anti-Biofilm Effect of Egg Yolk Phosvitin by Inhibition of Biomass Production and Adherence Activity against Streptococcus mutans." Food Science of Animal Resources 40, no. 6 (2020): 1001. doi:10.5851/kosfa.2020.e71.

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Copyright Owner

Korean Society for Food Science of Animal Resources

Language

en

File Format

application/pdf

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