Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis

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2012-01-01
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Mann, Francis
Peters, Reuben
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Peters, Reuben
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Biochemistry, Biophysics and Molecular Biology
Abstract

The actinomycetes family of bacteria is classically considered a rich source of natural products [1]. It is often suggested that such compounds have been selected by evolution to have biological activity [2]. For example, given the microbial-rich soil environment of the actinomycetes native habitat, their natural products have been suggested to serve in chemical warfare and/or signaling, which has been further connected to their leading role in providing pharmaceutically relevant antibiotic agents [3]. Nevertheless, surprisingly few of these molecules have been definitively assigned specific physiological roles in the native producing bacteria.

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This is a manuscript of an article published as Mann, F.M., Peters, R.J. (2012) “Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis”, Med. Chem. Commun., 3(8):899-904, doi: 10.1039/C2MD20030A. Posted with permission.

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Sun Jan 01 00:00:00 UTC 2012
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