Biochemistry, Biophysics and Molecular Biology
Journal or Book Title
Journal of the American Chemical Society
Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection.
American Chemical Society
Mann, Francis M.; Xu, Meimei; Chen, Xiaoming; Fulton, D. Bruce; Russell, David G.; and Peters, Reuben J., "Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis" (2009). Biochemistry, Biophysics and Molecular Biology Publications. 119.