Campus Units
Biochemistry, Biophysics and Molecular Biology
Document Type
Article
Publication Version
Published Version
Publication Date
2009
Journal or Book Title
Organic Letters
Volume
11
Issue
22
First Page
5170
Last Page
5173
DOI
10.1021/ol902051v
Abstract
Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.
Copyright Owner
American Chemical Society
Copyright Date
2009
Language
en
File Format
application/pdf
Recommended Citation
Gao, Wei; Hillwig, Matthew L.; Huang, Luqi; Cui, Guanghong; Wang, Xueyong; Kong, Jianqiang; Yang, Bin; and Peters, Reuben J., "A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights" (2009). Biochemistry, Biophysics and Molecular Biology Publications. 124.
https://lib.dr.iastate.edu/bbmb_ag_pubs/124
Included in
Biochemistry Commons, Genetics and Genomics Commons, Molecular Biology Commons, Plant Sciences Commons, Structural Biology Commons
Comments
This article is published as A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights, Wei Gao, Matthew L. Hillwig, Luqi Huang, Guanghong Cui, Xueyong Wang, Jianqiang Kong, Bin Yang, and Reuben J. Peters, Organic Letters 2009 11 (22), 5170-5173, DOI: 10.1021/ol902051v. This article is made available via ACS AuthorChoice.