Biochemistry, Biophysics and Molecular Biology, Roy J. Carver Department of, Baker Center for Bioinformatics and Biological Statistics
Journal or Book Title
Journal of Biomolecular Structure and Dynamics
The association of a drug with its target protein has the effect of blocking the protein activity and is termed a promiscuous function to distinguish from the protein’s native function (Tawfik and associates, Nat. Genet. 37, 73-6, 2005). Obviously, a protein has not evolved naturally for drug association or drug resistance. Promiscuous protein functions exhibit unique traits of evolutionary adaptability, or evolvability, which is dependent on the induction of novel phenotypic traits by a small number of mutations. These mutations might have small effects on native functions, but large effects on promiscuous function; for example, an evolving protein could become increasingly drug resistant while maintaining its original function.
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Fernandez, Ariel; Tawfik, Dan S.; Berkhout, Ben; Sanders, Rogier W.; Kloczkowski, Andrzej; Sen, Taner Z.; and Jernigan, Robert L., "Protein Promiscuity: Drug Resistance and Native Functions—HIV-1 Case" (2005). Biochemistry, Biophysics and Molecular Biology Publications. 167.