Document Type

Article

Publication Version

Published Version

Publication Date

6-2010

Journal or Book Title

Cold Spring Harbor Perspectives in Biology

Volume

2

First Page

1

Last Page

23

DOI

10.1101/cshperspect.a002287

Abstract

The Tec family tyrosine kinases regulate lymphocyte development, activation, and differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of the T-cell receptor to regulate phospholipase C-γ. This review highlights recent advances in our understanding of Itk kinase structure and enzymatic regulation, focusing on Itk protein domain interactions and mechanisms of substrate recognition. We also discuss the role of Itk in the development of conventional versus innate T-cell lineages, including both αβ and γδ T-cell subsets. Finally, we describe the complex role of Itk signaling in effector T-cell differentiation and the regulation of cytokine gene expression. Together, these data implicate Itk as an important modulator of T-cell signaling and function.

Comments

This article is from Cold Spring Harbor Perspectives in Biology 2 (2010): a002287, doi:10.1101/cshperspect.a002287.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf

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