Biochemistry, Biophysics and Molecular Biology, Roy J. Carver Department of
Journal or Book Title
The upregulation of the JIL-1 kinase on the male X chromosome and its association with the MSL complex suggest that JIL-1 may play a role in regulating dosage compensation. To directly test this hypothesis we measured eye pigment levels of mutants in the X-linked white gene in an allelic series of JIL-1 hypomorphic mutants. We show that dosage compensation of wa alleles that normally do exhibit dosage compensation was severely impaired in the JIL-1 mutant backgrounds. As a control we also examined a hypomorphic white allele we that fails to dosage compensate in males due to a pogo element insertion. In this case the relative pigment level measured in males as compared to females remained approximately the same even in the most severe JIL-1 hypomorphic background. These results indicate that proper dosage compensation of eye pigment levels in males controlled by X-linked white alleles requires normal JIL-1 function.
Lerach, Stephanie; Zhang, Weiguo; Deng, Huai; Bao, Xiaomin; Girton, Jack; Johansen, Jorgen; and Johansen, Kristen M., "JIL‐1 kinase, a member of the male‐specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila" (2005). Biochemistry, Biophysics and Molecular Biology Publications. 224.