Campus Units

Biochemistry, Biophysics and Molecular Biology, Roy J. Carver Department of

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

12-2005

Journal or Book Title

Genesis

Volume

43

Issue

4

First Page

213

Last Page

215

DOI

10.1002/gene.20172

Abstract

The upregulation of the JIL-1 kinase on the male X chromosome and its association with the MSL complex suggest that JIL-1 may play a role in regulating dosage compensation. To directly test this hypothesis we measured eye pigment levels of mutants in the X-linked white gene in an allelic series of JIL-1 hypomorphic mutants. We show that dosage compensation of wa alleles that normally do exhibit dosage compensation was severely impaired in the JIL-1 mutant backgrounds. As a control we also examined a hypomorphic white allele we that fails to dosage compensate in males due to a pogo element insertion. In this case the relative pigment level measured in males as compared to females remained approximately the same even in the most severe JIL-1 hypomorphic background. These results indicate that proper dosage compensation of eye pigment levels in males controlled by X-linked white alleles requires normal JIL-1 function.

Comments

This is the peer reviewed version of the following article: Lerach, Stephanie, Weiguo Zhang, Huai Deng, Xiaomin Bao, Jack Girton, Jørgen Johansen, and Kristen M. Johansen. "JIL‐1 kinase, a member of the male‐specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila." Genesis 43, no. 4 (2005): 213-215, which has been published in final form at doi: 10.1002/gene.20172. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Copyright Owner

Wiley‐Liss, Inc.

Language

en

File Format

application/pdf

Published Version

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