Campus Units

Biochemistry, Biophysics and Molecular Biology, Roy J. Carver Department of

Document Type

Article

Publication Version

Published Version

Publication Date

7-10-2020

Journal or Book Title

Organic & Biomolecular Chemistry

Volume

18

First Page

5586

Last Page

5588

DOI

10.1039/D0OB01422B

Abstract

The class II diterpene cyclase (DTC) from pleuromutilin biosynthesis uniquely mediates ‘A’ ring contraction of the initially formed decalin bicycle, yielding mutildienyl diphosphate (MPP). Catalysis requires a divalent metal cation co-factor. Intriguingly, selectively with magnesium, this DTC catalyzes ring expansion/contraction between MPP and halimadienyl diphosphate, providing some catalytic insight.

Comments

This article is published as Lemke, Cody, Owen Whitham, and Reuben J. Peters. "Magnesium-specific ring expansion/contraction catalysed by the class II diterpene cyclase from pleuromutilin biosynthesis." Organic & Biomolecular Chemistry 18 (2020): 5586-5588. doi:10.1039/D0OB01422B.

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

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