Biochemistry, Biophysics and Molecular Biology, Zoology
Journal or Book Title
Cell Biology International Reports
We have shown that serum, fibroblast growth factor, epidermal growth factor, and the tumour promotor, 12-O-tetradecanoylphorbol- 13-acetate (TPA), selectively induce the synthesis of certain secreted proteins in a variety of cell types. Similarly, a specific growth inhibitor protein selectively induces the synthesis of a secreted protein that is different from those induced by growth factors. In each case, the average increase in labeling by [3%]methionine of these secreted proteins after their induction is 7- to 10-fold. No correspondingly large increase is detected for intracellular proteins.
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Nilsen-Hamilton, Marit and Hamilton, Richard T., "Secreted proteins induced by growth factors and inhibitors" (1983). Biochemistry, Biophysics and Molecular Biology Publications. 36.