Biochemistry, Biophysics and Molecular Biology, Mechanical Engineering
Journal or Book Title
Applied Physics Letters
We report a sensor consisting of two micromachined cantilevers (a sensing/reference pair) that is suitable for detection of chemical and biological species. The sensing strategy involves coating the sensing cantilever with receptors that have high affinities for the analyte. The presence of analyte is detected by determining the differential surface stress associated with its adsorption/absorption to the sensing cantilever. An interferometric technique is utilized to measure the differential bending of the sensing cantilever with respect to reference. Surface stress associated with hybridization of single stranded DNA is measured to demonstrate the unique advantages of the sensor.
American Institute of Physics
Kang, K.; Nilsen-Hamilton, Marit; and Shrotriya, Pranav, "Differential surface stress sensor for detection of chemical and biological species" (2008). Biochemistry, Biophysics and Molecular Biology Publications. 40.