Biochemistry, Biophysics and Molecular Biology, Roy J. Carver Department of
Journal or Book Title
Organic & Biomolecular Chemistry
Miltiradiene (1), is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3).
The Royal Society of Chemistry
Zi, Jiachen and Peters, Reuben J., "Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae" (2013). Biochemistry, Biophysics and Molecular Biology Publications. 86.