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Submissions from 2014

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Functional Conservation of the Capacity for ent-Kaurene Biosynthesis and an Associated Operon in Certain Rhizobia, David M. Hershey, Xuan Lu, Jiachen Zi, and Reuben J. Peters

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An adaptable pentaloop defines a robust neomycin-B RNA aptamer with conditional ligand-bound structures, Muslum Ilgu, D. Bruce Fulton, Ragothaman M. Yennamalli, Monica H. Lamm, Taner Z. Sen, and Marit Nilsen-Hamilton

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Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization, Alana J. Jackson, David M. Hershey, Taylor Chesnut, Meimei Xu, and Reuben J. Peters

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Evaluating PHA Productivity of Bioengineered Rhodosprillum rubrum, Huanan Jin and Basil Nikolau

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1.55 Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis, Mustafa Köksal, Kevin Potter, Reuben J. Peters, and David W. Christianson

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Factors correlating with significant differences between X-ray structures of myoglobin, Alexander A. Rashin, Marcin J. Domagalski, Michael T. Zimmermann, Wladek Minor, Maksymilian Chruszcz, and Robert L. Jernigan

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Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins, Eric A. Schmelz, Alisa Huffaker, James W. Sims, Shawn A. Christensen, Xuan Lu, Kuzunori Okada, and Reuben J. Peters

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Live-cell imaging of Pol II promoter activity to monitor gene expression with RNA IMAGEtag reporters, Ilchung Shin, Judhajeet Ray, Vinayak Gupta, Muslum Ilgu, Jonathan Scott Beasley, Lee Bendickson, Samir Mehanovic, George A. Kraus, and Marit Nilsen-Hamilton

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Histone H3S10 phosphorylation by the JIL-1 kinase in pericentric heterochromatin and on the fourth chromosome creates a composite H3S10phK9me2 epigenetic mark, Chao Wang, Yeran Li, Weili Cai, Xiaomin Bao, Jack Girton, Jorgen Johansen, and Kristen M. Johansen

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Calmodulin and PI(3,4,5)P3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production, Xinxin Wang, Scott E. Boyken, Jiancheng Hu, Xiaolu Xu, Ryan P. Rimer, Madeline A. Shea, Andrey S. Shaw, Amy H. Andreotti, and Yina H. Huang

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A Selective NMR Probe to Monitor the Conformational Transition from Inactive to Active Kinase, Qian Xie, D. Bruce Fulton, and Amy H. Andreotti

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Characterization of an Orphan Diterpenoid Biosynthetic Operon from Salinispora arenicola, Meimei Xu, Matthew L. Hillwig, Amy L. Lane, Mollie Tiernan, Bradley S. Moore, and Reuben J. Peters

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The Spindle Matrix Protein, Chromator, Is a Novel Tubulin Binding Protein That Can Interact with Both Microtubules and Free Tubulin, Changfu Yao, Chao Wang, Yeran Li, Yun Ding, Uttama Rath, Saheli Sengupta, Jack Girton, Kristen M. Johansen, and Jorgen Johansen

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To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism, Jiachen Zi, Sibongile Mafu, and Reuben J. Peters

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Biosynthesis of Lycosantalonol, a cis-Prenyl Derived Diterpenoid, Jiachen Zi, Yuki Matsuba, Young J. Hong, Alana Jackson, Dean J. Tantillo, Eran Pichersky, and Reuben J. Peters

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Elastic network models capture the motions apparent within ensembles of RNA structures, Michael T. Zimmermann and Robert L. Jernigan

Submissions from 2013

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Distributions of amino acids suggest that certain residue types more effectively determine protein secondary structure, S. Saraswathi Battelle, J .L. Fernández-Martínez, A. Koliński, R. L. Jernigan, and A. Kloczkowski Battelle

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Integrated Self-Assembly of the Mms6 Magnetosome Protein to Form an Iron-Responsive Structure, Shuren Feng, Lijun Wang, Pierre E. Palo, Xunpei Liu, Surya K. Mallapragada, and Marit Nilsen-Hamilton

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The effect of JIL-1 on position-effect variegation is proportional to the total amount of heterochromatin in the genome, Jack Girton, Chao Wang, Jorgen Johansen, and Kristen M. Johansen

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Activation Loop Dynamics Determine the Different Catalytic Efficiencies of B Cell– and T Cell–Specific Tec Kinases, Raji E. Joseph, Iivari Kleino, Thomas E. Wales, Qian Xie, D. Bruce Fulton, John R. Engen, Leslie J. Berg, and Amy H. Andreotti

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Domain Requirements of the JIL-1 Tandem Kinase for Histone H3 Serine 10 Phosphorylation and Chromatin Remodeling in Vivo, Yeran Li, Weili Cai, Chao Wang, Changfu Yao, Xiaomin Bao, Huai Deng, Jack Girton, Jorgen Johansen, and Kristen M. Johansen

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Coarse Grained Normal Mode Analysis vs. Refined Gaussian Network Model for Protein Residue-Level Structural Fluctuations, Jun-Koo Park, Robert Jernigan, and Zhijun Wu

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Evidence against a Role for the JIL-1 Kinase in H3S28 Phosphorylation and 14-3-3 Recruitment to Active Genes in Drosophila, Chao Wang, Changfu Yao, Yeran Li, Weili Cai, Xiaomin Bao, Jack Girton, Jorgen Johansen, and Kristen M. Johansen

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Fidelity, Mismatch Extension, and Proofreading Activity of the Plasmodium falciparum Apicoplast DNA Polymerase, Bentley Wingert, Eric Evan Parrott, and Scott W. Nelson

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Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis, Yisheng Wu, Qiang Wang, Matthew L. Hillwig, and Reuben J. Peters

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Substrate Recognition of PLCγ1 via a Specific Docking Surface on Itk, Qian Xie, Raji E. Joseph, D. Bruce Fulton, and Amy H. Andreotti

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Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae, Jiachen Zi and Reuben J. Peters

Submissions from 2012

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Disruption of the Bacteriophage T4 Mre11 Dimer Interface Reveals a Two-state Mechanism for Exonuclease Activity, Dustin William Albrecht, Timothy J. Herdendorf, and Scott W. Nelson

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A Computational Investigation on the Connection between Dynamics Properties of Ribosomal Proteins and Ribosome Assembly, Brittany Burton, Michael T. Zimmermann, Robert L. Jernigan, and Yongmei Wang

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A Single Residue Change Leads to a Hydroxylated Product from the Class II Diterpene Cyclization Catalyzed by Abietadiene Synthase, Jared Criswell, Kevin Potter, Freya Shephard, Michael H. Beale, and Reuben J. Peters

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Terpenoid synthase structures: a so far incomplete view of complex catalysis, Yang Gao, Richard B. Honzatko, and Reuben J. Peters

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Elastic network normal modes provide a basis for protein structure refinement, Pawel Gniewek, Andrzej Kolinski, Robert L. Jernigan, and Andrzej Kloczkowski

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How noise in force fields can affect the structural refinement of protein models, Pawel Gniewek, Andrzej Kolinski, Robert L. Jernigan, and Andrzej Kloczkowski

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P.R.E.S.S. – An R-package for Exploring Residual-Level Protein Structural Statistics, Yuanyuan Huang, Steve Bonett, Andrzej Klockowski, Robert Jernigan, and Zhijun Wu

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Role of Genetic Redundancy in Polyhydroxyalkanoate (PHA) Polymerases in PHA Biosynthesis in Rhodospirillum rubrum, Huanan Jin and Basil Nikolau

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Structure of the Interleukin-2 Tyrosine Kinase Src Homology 2 Domain; Comparison Between X-ray and NMR-Derived Structures, Raji E. Joseph, Nathaniel D. Ginder, Julie Anne Hoy, Jay C. Nix, D. Bruce Fulton, Richard B. Honzatko, and Amy H. Andreotti

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In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase, Roman M. Levytskyy, Nupura Hirve, David M. Guimond, Lie Min, Amy H. Andreotti, and Constantine D. Tsoukas

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Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis, Francis M. Mann and Reuben J. Peters

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Functional Characterization and Evolution of the Isotuberculosinol Operon in Mycobacterium Tuberculosis and Related Mycobacteria, Francis M. Mann, Meimei Xu, Emily Kaitlin Davenport, and Reuben J. Peters

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Developmental Changes in the Metabolic Network of Snapdragon Flowers, Joelle K. Muhlemann, Hiroshi Maeda, Ching-Yun Chang, Phillip San Miquel, Ivan Baxter, Bruce Cooper, Ann Perera, Basil Nikolau, Olga Vitek, John A. Morgan, and Natalia Dudareva

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Identification of Fluorescent Compounds with Non-Specific Binding Property via High Throughput Live Cell Microscopy, Sangeeta Nath, Virginia A. Spencer, Ju Han, Hang Chang, Kai Zhang, Gerald V. Fontenay, Charles Anderson, Joel M. Hyman, Marit Nilsen-Hamilton, Young-Tae Chang, and Bahram Parvin

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Metabolomics as a hypothesis-generating functional genomics tool for the annotation of Arabidopsis thaliana genes of “unknown function”, Stephanie M. Quanbeck, Libuse Brachova, Alexis A. Campbell, Xin Guan, Ann Perera, Kun He, Seung Y. Rhee, Preeti Bais, Julie A. Dickerson, Philip M. Dixon, Gert Wohlgemuth, Oliver Fiehn, Lenore Barkan, Iris Lange, B. Markus Lange, Insuk Lee, Diego Cortes, Carolina Salazar, Joel Shuman, Vladimir Shulaev, David V. Huhman, Lloyd W. Sumner, Mary R. Roth, Ruth Welti, Hilal Ilarslan, Eve S. Wurtele, and Basil J. Nikolau

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Fast learning optimized prediction methodology (FLOPRED) for protein secondary structure prediction, Saras Saraswathi, Juan Luis Fernandez-Martinez, Andrzej Kolinski, Robert L. Jernigan, and Andrzej Kloczkowski

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The Importance of Slow Motions for Protein Functional Loops, Aris Skliros, Michael T. Zimmermann, Debkanta Chakraborty, Saras Saraswathi, Ataur R. Katebi, Sumudu P. Leelananda, Andrzej Kloczkowski, and Robert L. Jernigan

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Phytohormone signaling pathway analysis method for comparing hormone responses in plant-pest interactions, Matthew Edward Studham and Gustavo C. Macintosh

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Self-Assembly and Biphasic Iron-Binding Characteristics of Mms6, A Bacterial Protein That Promotes the Formation of Superparamagnetic Magnetite Nanoparticles of Uniform Size and Shape, Lijun Wang, Tanya Prozorov, Pierre E. Palo, Xunpei Liu, David Vaknin, Ruslan Prozorov, Surya K. Mallapragada, and Marit Nilsen-Hamilton

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Characterization of CYP76M5–8 Indicates Metabolic Plasticity within a Plant Biosynthetic Gene Cluster, Qiang Wang, Matthew L. Hillwig, Kazunori Okada, Kohei Yamazaki, Yisheng Wu, Sivakumar Swaminathan, Hisakazu Yamane, and Reuben J. Peters

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CYP701A8: A Rice ent-Kaurene Oxidase Paralog Diverted to More Specialized Diterpenoid Metabolism, Qiang Wang, Matthew L. Hillwig, Yisheng Wu, and Reuben J. Peters

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Interfacial Properties and Iron Binding to Bacterial Proteins That Promote the Growth of Magnetite Nanocrystals: X-ray Reflectivity and Surface Spectroscopy Studies, Wenjie Wang, Wei Bu, Lijun Wang, Pierre E. Palo, Surya K. Mallapragada, Marit Nilsen-Hamilton, and David Vaknin

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Medicinal Plants: A Public Resource for Metabolomics and Hypothesis Development, Eve Syrkin Wurtele, Joe Chappell, A. Daniel Jones, Mary Dawn Celiz, Nick Ransom, Manhoi Hur, Ludmila Rizshsky, Matthew Crispin, Philip Dixon, Jia Liu, Mark P. Widrlechner, and Basil J. Nikolau

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Functional characterization of wheat copalyl diphosphate synthases sheds light on the early evolution of labdane-related diterpenoid metabolism in the cereals, Yisheng Wu, Ke Zhou, Tomonobu Toyomasu, Chizu Sugawara, Madoka Oku, Shiho Abe, Masami Usui, Wataru Mitsuhashi, Makiko Chono, Peter M. Chandler, and Reuben J. Peters

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Genetic evidence for natural product-mediated plant–plant allelopathy in rice (Oryza sativa), Meimei Xu, Rita Galhano, Philipp Wiemann, Emilio Bueno, Mollie Tiernan, William Wu, Ill-Min Chung, Jonathan Gershenzon, Bettina Tudzynski, Ane Sesma, and Reuben J. Peters

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The chromodomain-containing NH2-terminus of Chromator interacts with histone H1 and is required for correct targeting to chromatin, Changfu Yao, Yun Ding, Weili Cai, Chao Wang, Jack Girton, Kristen M. Johansen, and Jorgen Johansen

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A nuclear-derived proteinaceous matrix embeds the microtubule spindle apparatus during mitosis, Changfu Yao, Uttama Rath, Helder Maiato, David Sharp, Jack Girton, Kristen M. Johansen, and Jorgen Johansen

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An RNA Aptamer-Based Microcantilever Sensor To Detect the Inflammatory Marker, Mouse Lipocalin-2, Lijie Zhai, Tianjiao Wang, Kyungho Kang, Yue Zhao, Pranav Shrotriya, and Marit Nilsen-Hamilton

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Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis, Ke Zhou, Yang Gao, Julie A. Hoy, Francis M. Mann, Richard B. Honzatko, and Reuben J. Peters

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Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals, Ke Zhou, Meimei Xu, Mollie Tiernan, Qian Xie, Tomonobu Toyomasu, Chizu Sugawara, Madoka Oku, Masami Usui, Wataru Mitsuhashi, Makiko Chono, and Peter M. Chandler

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Protein Loop Dynamics Are Complex and Depend on the Motions of the Whole Protein, Michael T. Zimmermann and Robert L. Jernigan

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Effect of Isotopically Sensitive Branching on Product Distribution for Pentalenene Synthase: Support for a Mechanism Predicted by Quantum Chemistry, Liansuo Zu, Meimei Xu, Michael W. Lodewyk, David E. Cane, Reuben J. Peters, and Dean J. Tantillo

Submissions from 2011

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A nuclear magnetic resonance based approach to accurate functional annotation of putative enzymes in the methanogen Methanosarcina acetivorans, Yihong Chen, Ethel Apolinario, Libuse Brachova, Zvi Kelman, Zhuo Li, Basil Nikolau, Lucas John Showman, Kevin Sowers, and John Orban

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An Interaction between the Walker A and D-loop Motifs Is Critical to ATP Hydrolysis and Cooperativity in Bacteriophage T4 Rad50, Metzere Bierlein De la Rosa and Scott W. Nelson

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MultiBody Coarse-Grained Potentials for Native Structure Recognition and Quality Assessment of Protein Models, Pawel Gniewek, Sumudu P. Leelananda, Andrzej Kolinski, Robert L. Jernigan, and Andrzej Kloczkowski

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Biochemical Characterization of Bacteriophage T4 Mre11-Rad50 Complex, Timothy J. Herdendorf; Dustin William Albrecht; Stephen J. Benkovic; and Scott W, Nelson

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Functional Evaluation of Bacteriophage T4 Rad50 Signature Motif Residues, Timothy J. Herdendorf and Scott W. Nelson

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Diterpenoid biopolymers: New directions for renewable materials engineering, Matthew L. Hillwig, Francis M. Mann, and Reuben J. Peters

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Domain loss has independently occurred multiple times in plant terpene synthase evolution, Matthew L. Hillwig, Meimei Xu, Tomonobu Toyomasu, Mollie S. Tiernan, Gao Wei, Guanghong Cui, Luqi Huang, and Reuben J. Peters

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Statistical Measures on Residue-Level Protein Structural Properties, Yuanyuan Huang, Steve Bonett, Andrzej Kloczkowski, Robert L. Jernigan, and Zhijun Wu

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Purification, Crystallization and Preliminary Crystallographic Analysis of the SH2 Domain of IL-2-inducible T-cell Kinase, Raji E. Joseph, Nathaniel D. Ginder, Julie A. Hoy, Jay C. Nix, Richard B. Honzatko, and Amy H. Andreotti

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Aptamer Functionalized Microcantilever Sensors for Cocaine Detection, Kyungho Kang, Ashish Sachan, Marit Nilsen-Hamilton, and Pranav Shrotriya

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Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase, Mustafa Köksal, Huayou Hu, Robert M. Coates, Reuben J. Peters, and David D. Christianson

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Exploration of the relationship between topology and designability of conformations, Sumudu P. Leelananda, Fadi Towfic, Robert L. Jernigan, and Andrzej Kloczkowski

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A Novel Labda-7,13E-dien-15-ol-Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii, Sibongile Mafu, Matthew L. Hillwig, and Reuben J. Peters

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Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis, Francis M. Mann, Jill A. Thomas, and Reuben J. Peters

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Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis, Francis M. Mann, Brian C. VanderVen, and Reuben J. Peters

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Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals, Dana Morrone, Matthew L. Hillwig, Matthew E. Mead, Luke Lowry, D. Bruce Fulton, and Reuben J. Peters

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Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli, Chih-Chia Su, Feng Long, Michael T. Zimmermann, Kanagalaghatta R. Rajashankar, Robert L. Jernigan, and Edward W. Yu

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The epigenetic H3S10 phosphorylation mark is required for counteracting heterochromatic spreading and gene silencing in Drosophila melanogaster, Chao Wang, Weili Cai, Yeran Li, Huai Deng, Xiaomin Bao, Jack Girton, Jorgen Johansen, and Kristen M. Johansen

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CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice, Qiang Wang, Matthew L. Hillwig, and Reuben J. Peters

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Analysis of protein dynamics using local-DME calculations, Di Wu, Stephen Smith, Hannah Mahan, Robert L. Jernigan, and Zhijun Wu

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Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7, Yinsheng Wu, Matthew L. Hillwig, Qiang Wang, and Reuben J. Peters

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Deficiency of maize starch-branching enzyme i results in altered starch fine structure, decreased digestibility and reduced coleoptile growth during germination, Huan Xia, Marna Yandeau-Nelson, Donald B. Thompson, and Mark J. Guiltinan

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Electrostatic effects on (di)terpene synthase product outcome, Ke Zhou and Reuben J. Peters

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MAVENs: motion analysis and visualization of elastic networks and structural ensembles, Michael T. Zimmermann, Andrzej Kloczkowski, and Robert L. Jernigan

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Free energies for coarse-grained proteins by integrating multibody statistical contact potentials with entropies from elastic network models, Michael T. Zimmermann, Sumudu P. Leelananda, Pawel Gniewek, Yaping Feng, Robert L. Jernigan, and Andrzej Kloczkowski

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Immunoglobulin Structure Exhibits Control over CDR Motion, Michael T. Zimmermann, Aris Skliros, Andrzej Kloczkowski, and Robert L. Jernigan

Submissions from 2010

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T-Cell Signaling Regulated by the Tec Family Kinase, Itk, Amy H. Andreotti, Pamela L. Schwartzberg, Raji E. Joseph, and Leslie J. Berg

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T Cell Specific Adapter Protein (TSAd) Interacts with Tec Kinase ITK to Promote CXCL12 Induced Migration of Human and Murine T Cells, Tone Berge, Vibeke Sundvold-Gjerstad, Stine Granum, Thorny Cecilie Bie Andersen, Gunn B. Holthe, Lena Claesson-Welsh, Amy H. Andreotti, Marit Inngjerdingen, and Anne Spurkland

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Phosphorylation of SU(VAR)3–9 by the Chromosomal Kinase JIL-1, Joern Boeke, Catherine Regnard, Weili Cai, Jorgen Johansen, Kristen M. Johansen, Peter B. Becker, and Axel Imhof

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Preparation of Drosophila Polytene Chromosome Squashes for Antibody Labeling, Weili Cai, Ye Jin, Jack Girton, Jorgen Johansen, and Kristen M. Johansen

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Diterpene cyclases and the nature of the isoprene fold, Rong Cao, Yonghui Zhang, Francis M. Mann, Cancan Huang, Dushyant Mukkamala, Michael P. Hudock, Matthew Mead, Sladjana Prisic, Ke Wang, Fu-Yang Lin, Ting-Kai Chang, Reuben Peters, and Eric Oldfield

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Potentials 'R'Us web-server for protein energy estimations with coarse-grained knowledge-based potentials, Yaping Feng, Andrzej Kloczkowski, and Robert L. Jernigan

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Petunia nectar proteins have ribonuclease activity, Melissa Sue Hillwig, Xiaoteng Liu, Guangyu Liu, Robert W. Thornburg, and Gustavo C. Macintosh

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Controlling the Activity of the Tec Kinase Itk by Mutation of the Phenylalanine Gatekeeper Residue, Raji E. Joseph and Amy H. Andreotti

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Identification of an Allosteric Signaling Network within Tec Family Kinases, Raji E. Joseph, Qian Xie, and Amy H. Andreotti

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Structural interpretation of protein-protein interaction network, Ataur R. Katebi, Andrzej Kloczkowski, and Robert L. Jernigan

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Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport, Feng Long, Chih-Chia Su, Michael T. Zimmermann, Scott E. Boyken, Kanagalaghatta R. Rajashankar, Robert L. Jernigan, and Edward W. Yu

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A Single Residue Switch for Mg2+-dependent Inhibition Characterizes Plant Class II Diterpene Cyclases from Primary and Secondary Metabolism, Francis M. Mann, Sladjana Prisic, Emily K. Davenport, Mara K. Determan, Robert M. Coates, and Reuben J. Peters

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Synthesis of (±)-Nosyberkol (Isotuberculosinol, Revised Structure of Edaxadiene) and (±)-Tuberculosinol, Nathan Maugel, Francis M. Mann, Matthew L. Hillwig, Reuben J. Peters, and Barry B. Snider

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Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering, Dana Morrone, Luke Lowry, Mara K. Determan, David M. Hershey, Meimei Xu, and Reuben J. Peters

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Two rings in them all: The labdane-related diterpenoids, Reuben J. Peters