Campus Units

Office of Biotechnology

Document Type

Article

Publication Version

Published Version

Publication Date

11-11-2016

Journal or Book Title

Molecules

Volume

21

Issue

11

First Page

1510

DOI

10.3390/molecules21111510

Abstract

The tropane and granatane alkaloids belong to the larger pyrroline and piperidine classes of plant alkaloids, respectively. Their core structures share common moieties and their scattered distribution among angiosperms suggest that their biosynthesis may share common ancestry in some orders, while they may be independently derived in others. Tropane and granatane alkaloid diversity arises from the myriad modifications occurring to their core ring structures. Throughout much of human history, humans have cultivated tropane- and granatane-producing plants for their medicinal properties. This manuscript will discuss the diversity of their biological and ecological roles as well as what is known about the structural genes and enzymes responsible for their biosynthesis. In addition, modern approaches to producing some pharmaceutically important tropanes via metabolic engineering endeavors are discussed.

Comments

This article is published as Kim, Neill, Olga Estrada, Benjamin Chavez, Charles Stewart, and John C. D’Auria. "Tropane and granatane alkaloid biosynthesis: a systematic analysis." Molecules 21, no. 11 (2016): 1510. DOI: 10.3390/molecules21111510. Posted with permission.

Copyright Owner

The Author(s)

Language

en

File Format

application/pdf

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