Campus Units

Biomedical Sciences

Document Type

Article

Publication Version

Published Version

Publication Date

6-2014

Journal or Book Title

EuPA Open Proteomics

Volume

3

First Page

262

Last Page

272

DOI

10.1016/j.euprot.2014.04.002

Abstract

FMRFamide-like peptide (FLP) receptors are appealing as putative anthelmintic targets. To date, 31 flp-encoding genes have been identified in Caenorhabditis elegans and thirteen FLP-activated G-protein coupled receptors (FLP-GPCRs) have been reported. The lack of knowledge on FLPs and FLP-GPCRs in parasites impedes their functional characterisation and chemotherapeutic exploitation. Using homology-based BLAST searches and phylogenetic analyses this study describes the identification of putative flpand flp-GPCR gene homologues in 17 nematode parasites providing the first pan-phylum genome-based overview of the FLPergic complement. These data will facilitate FLP-receptor deorphanisation efforts in the quest for novel control targets for nematode parasites.

Comments

This article is from EuPA Open Proteomics 3 (2014): 262–272, doi:10.1016/j.euprot.2014.04.002. Posted with permission.

Rights

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).

Copyright Owner

McCoy et al

Language

en

File Format

application/pdf

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