Journal or Book Title
EuPA Open Proteomics
FMRFamide-like peptide (FLP) receptors are appealing as putative anthelmintic targets. To date, 31 flp-encoding genes have been identified in Caenorhabditis elegans and thirteen FLP-activated G-protein coupled receptors (FLP-GPCRs) have been reported. The lack of knowledge on FLPs and FLP-GPCRs in parasites impedes their functional characterisation and chemotherapeutic exploitation. Using homology-based BLAST searches and phylogenetic analyses this study describes the identification of putative flpand flp-GPCR gene homologues in 17 nematode parasites providing the first pan-phylum genome-based overview of the FLPergic complement. These data will facilitate FLP-receptor deorphanisation efforts in the quest for novel control targets for nematode parasites.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
McCoy et al
McCoy, Ciaran J.; Atkinson, Louise E.; Zamanian, Mostafa; McVeigh, Paul; Day, Timothy A.; Kimber, Michael J.; Marks, Nikki J.; Maule, Aaron G.; and Mousley, Angela, "New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches" (2014). Biomedical Sciences Publications. 13.