Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative

Schneider, Benjamin; Balbas-Martinez, Violeta; Jergens, Albert; Mochel, Jonathan; Troconiz, Inaki; Allenspach, Karin; Mochel, Jonathan

Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative

File

2017_Mochel_ModelBased.pdf (319.5 KB)

Date

2017-01-01

Authors

Schneider, Benjamin

Balbas-Martinez, Violeta

Jergens, Albert

Mochel, Jonathan

Troconiz, Inaki

Allenspach, Karin

Mochel, Jonathan

Authors

Person

Mochel, Jonathan

Researcher

Organizational Units

Organizational Unit

Biomedical Sciences

The Department of Biomedical Sciences aims to provide knowledge of anatomy and physiology in order to understand the mechanisms and treatment of animal diseases. Additionally, it seeks to teach the understanding of drug-action for rational drug-therapy, as well as toxicology, pharmacodynamics, and clinical drug administration.

History
The Department of Biomedical Sciences was formed in 1999 as a merger of the Department of Veterinary Anatomy and the Department of Veterinary Physiology and Pharmacology.

Dates of Existence
1999–present

Related Units

College of Veterinary Medicine (parent college)
Department of Veterinary Anatomy (predecessor, 1997)
Department of Veterinary Physiology and Pharmacology (predecessor, 1997)

Organizational Unit

Veterinary Clinical Sciences

The mission of the Veterinary Clinical Sciences Department and the Veterinary Medical Center is to be strong academically, to provide outstanding services, and to conduct research in the multiple areas of Veterinary Clinical Sciences. Our goals are to teach students in the multiple disciplines of Veterinary Clinical Sciences, to provide excellent veterinary services to clients, and to generate and disseminate new knowledge in the areas of Veterinary Clinical Sciences. Our objectives are to provide a curriculum in the various aspects of Veterinary Clinical Sciences which ensures students acquire the skills and knowledge to be successful in their chosen careers. We also strive to maintain a caseload of sufficient size and diversity which insures a broad clinical experience for students, residents, and faculty. In addition, we aim to provide clinical veterinary services of the highest standards to animal owners and to referring veterinarians. And finally, we strive to provide an environment and opportunities which foster and encourage the generation and dissemination of new knowledge in many of the disciplines of Veterinary Clinical Sciences.

Department

Biomedical SciencesVeterinary Clinical Sciences

Abstract

There is growing concern about the limitations of rodent models with regard to recapitulation of human disease pathogenesis. Computational modeling of data from humans and animals sharing similar diseases provides an opportunity for parallel drug development in human and veterinary medicine. This “reverse translational” approach needs to be supported by continuing efforts to refine the in silico tools that allow extrapolation of results between species.

Comments

This article is published as Schneider, Benjamin, Violeta Balbas‐Martinez, Albert E. Jergens, Inaki F. Troconiz, Karin Allenspach, and Jonathan P. Mochel. "Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative." CPT: pharmacometrics & systems pharmacology (2017). doi: 10.1002/psp4.12262. Posted with permission.

Copyright

Sun Jan 01 00:00:00 UTC 2017

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