Campus Units

Biomedical Sciences

Document Type

Article

Publication Version

Published Version

Publication Date

2016

Journal or Book Title

Journal of Bacteriology & Parasitology

Volume

7

Issue

5

First Page

294

DOI

10.4172/2155-9597.1000294

Abstract

The objective of this study was to investigate an interaction between nematodes and gut Enterobacteriaceae that use benzimidazoles as a carbon source. By addressing this objective, we identified an anthelmintic resistance-like mechanism for gastrointestinal nematodes. We isolated 30 gut bacteria (family Enterobacteriaceae) that subsist on and putatively catabolize benzimidazole-class anthelmintics. C. elegans was protected from the effects of benzimidazoles when co-incubated with these Enterobacteriaceae that also protect adult ascarids from the effects of albendazole. This bacterial phenotype represents a novel mechanism by which gastrointestinal nematodes are potentially spared from the effects of benzimidazoles, without any apparent fitness cost to the parasite.

Comments

This article is published as Whittaker JH, Robertson AP, Kimber MJ, Day TA, Carlson SA (2016) Intestinal Enterobacteriaceae that Protect Nematodes from the Effects of Benzimidazoles. J Bacteriol Parasitol 7:294. doi: 10.4172/2155-9597.1000294. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

Whittaker JH, et al.

Language

en

File Format

application/pdf

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